LAG-3/CD223 Recombinant monoclonal antibody 80867-1-RR proteintech
$149.00
In stock
SKU
80867-1-RR
| Catalog Number | 80867-1-RR |
| Synonyms | CD223, LAG3, 1F14, FDC, LAG 3 |
| Host | Rabbit |
| Reactivity | human, mouse |
| Form | Liquid |
| Formulation | PBS, Azide, Glycerol |
| Applications | WB, IF, ELISA |
| Applications | WB, ELISA |
| Host / Isotype | Rabbit / IgG |
| Tested Applications — Positive WB detected in | CTLL-2 cells |
| Recommended Dilutions — Western Blot (WB) | WB : 1:1000-1:8000 |
| Positive WB detected in | CTLL-2 cells |
| Western Blot (WB) | WB : 1:1000-1:8000 |
| Tested Reactivity | human, mouse |
| Cited Reactivity | human, mouse |
| Class | Recombinant |
| Type | Antibody |
| Immunogen | Recombinant protein Predict reactive species |
| Full Name | lymphocyte-activation gene 3 |
| Calculated Molecular Weight | 57 kDa |
| Observed Molecular Weight | 60 kDa |
| GenBank Accession Number | NM_002286 |
| Gene Symbol | LAG-3 |
| Gene ID (NCBI) | 3902 |
| RRID | AB_2918917 |
| Conjugate | Unconjugated |
| Purification Method | Protein A purification |
| UNIPROT ID | P18627 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA. |
| WB protocol for LAG-3/CD223 antibody 80867-1-RR | Download protocol |
| mouse | IF Cancer Lett The deubiquitinase USP2a promotes tumor immunosuppression by stabilizing immune checkpoint B7-H4 in lung adenocarcinoma harboring EGFR-activating mutants Authors - Youwei Lu View Article |
| human | WB Cancer Sci Screening of novel serum biomarkers for gastric cancer in coastal populations using a protein microarray Authors - Yongdong Yi View Article |
| Citations | 8 |
| Dilutions | WB : 1:1000-1:8000 |
| Isotype | IgG |
| Clonality | Recombinant |
| Clone Number | 1F14 |
| Conjugation | Unconjugated |
LAG-3, also known as CD223, is an immune checkpoint molecule that regulates both T-cell activation and homeostasis. LAG-3 is expressed on activated T cells, NK cells, regulatory T cells, and plasmacytoid dendritic cells. It is a CD4-related molecule that binds MHC class II. LAG-3 plays an important role in modulating T cell expansion and function, and blockade of LAG-3 with monoclonal antibodies can augment T cell function. (PMID: 15634887; 21086108; 28783703) Protocols Product Specific Protocols WB protocol for LAG-3/CD223 antibody 80867-1-RR Download protocol Standard Protocols Click here to view our Standard Protocols
Publications
- Neuroprotective effects of lixisenatide against propagation of α-synuclein pathology in Parkinson's disease
Journal: Neural Regen Res | Authors: Shangqi Sun | Species: mouse | Application: WB,IF - Xiao-Yao-San suppresses psychological distress-related colorectal cancer metastasis and enhances antitumor immune responses through regulating gut microbiota-bile acid axis.
Journal: Phytomedicine | Authors: Xinxin Hou - Engineering oral commensal nanovaccines to activate mucosal-systemic immune cascades against tumor.
Journal: Cell Host Microbe | Authors: Zirong Dong - Screening of novel serum biomarkers for gastric cancer in coastal populations using a protein microarray
Journal: Cancer Sci | Authors: Yongdong Yi | Species: human | Application: WB - The deubiquitinase USP2a promotes tumor immunosuppression by stabilizing immune checkpoint B7-H4 in lung adenocarcinoma harboring EGFR-activating mutants
Journal: Cancer Lett | Authors: Youwei Lu | Species: mouse | Application: IF - Histone H3K18 Lactylation Contributes to Perioperative Neurocognitive Disorder Through Immune Checkpoint Lymphocyte Activation Gene 3 Mediated Microglial Pyroptosis.
Journal: CNS Neurosci Ther | Authors: Chenglong Li - Screening of novel serum biomarkers for gastric cancer in coastal populations using a protein microarray
Journal: Cancer Sci | Authors: Yongdong Yi | Species: human | Application: WB - ARTN drives CD8(+) T cell exhaustion via the GFRα3-RET-PI3K/AKT Axis to promote TNBC progression.
Journal: Cell Signal | Authors: Dongke Yan
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