LTBP2 Polyclonal antibody 28824-1-AP proteintech
$149.00
In stock
SKU
28824-1-AP
| Catalog Number | 28824-1-AP |
| Synonyms | C14orf141, LTBP3, Latent-transforming growth factor beta-binding protein 2, LTBP 2, LTBP-2 |
| Host | Rabbit |
| Reactivity | human, mouse |
| Form | Liquid |
| Formulation | PBS, Azide, Glycerol |
| Applications | IHC, IF/ICC, IP, ELISA |
| Host / Isotype | Rabbit / IgG |
| Tested Applications — Positive IP detected in | U2OS cells |
| Tested Applications — Positive IHC detected in | mouse lung tissue, human lung tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Tested Applications — Positive IF/ICC detected in | U2OS cells |
| Recommended Dilutions — Immunoprecipitation (IP) | IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate |
| Recommended Dilutions — Immunohistochemistry (IHC) | IHC : 1:50-1:500 |
| Recommended Dilutions — Immunofluorescence (IF)/ICC | IF/ICC : 1:200-1:800 |
| Positive IP detected in | U2OS cells |
| Positive IHC detected in | mouse lung tissue, human lung tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Positive IF/ICC detected in | U2OS cells |
| Immunoprecipitation (IP) | IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate |
| Immunohistochemistry (IHC) | IHC : 1:50-1:500 |
| Immunofluorescence (IF)/ICC | IF/ICC : 1:200-1:800 |
| Tested Reactivity | human, mouse |
| Cited Reactivity | human, mouse |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | CatNo: Ag29737 Product name: Recombinant human LTBP2 protein Source: e coli. -derived, PET28a Tag: 6*His Domain: 241-376 aa of BC078659 Sequence: ERSPNLRRSSAAGEGTLARAQPPAPQSPPAPQSPPAGTLSGLSQTHPSQQHVGLSRTVRLHPTATASSQLSSNALPPGPGLEQRDGTQQAVPLEHPSSPWGLNLTEKIKKIKIVFTPTICKQTCARGHCANSCERG Predict reactive species |
| Full Name | latent transforming growth factor beta binding protein 2 |
| Calculated Molecular Weight | 1821 aa, 195 kDa |
| Observed Molecular Weight | 260 kDa |
| GenBank Accession Number | BC078659 |
| Gene Symbol | LTBP2 |
| Gene ID (NCBI) | 4053 |
| RRID | AB_3669670 |
| Conjugate | Unconjugated |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | Q14767 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA. |
| IF protocol for LTBP2 antibody 28824-1-AP | Download protocol |
| IHC protocol for LTBP2 antibody 28824-1-AP | Download protocol |
| IP protocol for LTBP2 antibody 28824-1-AP | Download protocol |
| human | IHC J Clin Endocrinol Metab High-Throughput Proteomics and Immunohistochemistry of Orbital Connective Tissue in Graves' Orbitopathy Authors - Yuanping Hai View Article |
| mouse | IHC Mol Cell Biochem Identification of disease-associated gene expression signatures for mechanistic insights and drug prediction in dilated cardiomyopathy-induced heart failure. Authors - Wei Yu View Article |
| Citations | 2 |
| Dilutions | IP : 0.5-4.0 ug for IP and 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate for WB IHC : 1:50-1:500 IF/ICC : 1:200-1:800 |
| Isotype | IgG |
| Clonality | Polyclonal |
| Clone Number | - |
| Conjugation | Unconjugated |
LTBP2, an extracellular glycoprotein mapping to chromosome 14q24, belongs to a family of latent TGF-β binding proteins (LTBPs) that regulates a well-known growth factor, TGF-β. LTBP2 is an elastic fiber-associating protein whose function in elastogenesis is not clear, as a DANCEbinding Protein. (PMID: 17581631 )It may play an integral structural role in elastic-fiber architectural organization and/or assembly. LTBP2 associates covalently with small latent TGF-beta complex via Repeat B and Repeat C. Defects in LTBP2 are the cause of primary congenital glaucoma type 3D (GLC3D). [MIM:613086] LTBP2 is a role in the structural stability of ciliary zonules, and growth and development of lens.(PMID: 20617341) LTBP2 null mutations in an autosomal recessive ocular syndrome with megalocornea, spherophakia, and secondary glaucoma (PMID: 20179738 ) . LTBP2 is a biomarker of heart failure. LTBP2 has a molecular weight of 260 kDa (PMID: 20878956), and even larger molecular weights of 290 and 310 kDa were detected in tissue extracts. (PMID: 8524260) Protocols Product Specific Protocols IF protocol for LTBP2 antibody 28824-1-AP Download protocol IHC protocol for LTBP2 antibody 28824-1-AP Download protocol IP protocol for LTBP2 antibody 28824-1-AP Download protocol Standard Protocols Click here to view our Standard Protocols
Publications
- High-Throughput Proteomics and Immunohistochemistry of Orbital Connective Tissue in Graves' Orbitopathy
Journal: J Clin Endocrinol Metab | Authors: Yuanping Hai | Species: human | Application: IHC - Identification of disease-associated gene expression signatures for mechanistic insights and drug prediction in dilated cardiomyopathy-induced heart failure.
Journal: Mol Cell Biochem | Authors: Wei Yu | Species: mouse | Application: IHC
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