LZTS2 Polyclonal antibody 15677-1-AP proteintech
$149.00
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SKU
15677-1-AP
| Catalog Number | 15677-1-AP |
| Synonyms | hLZTS2, LAPSER1, LZTS 2 |
| Host | Rabbit |
| Reactivity | human, mouse, rat |
| Form | Liquid |
| Formulation | PBS, Azide, Glycerol |
| Applications | WB, IHC, IF, IP, CoIP, ELISA |
| Applications | WB, IHC, ELISA |
| Host / Isotype | Rabbit / IgG |
| Tested Applications — Positive WB detected in | HeLa cells, PC-3 cells |
| Tested Applications — Positive IHC detected in | human prostate hyperplasia tissue, human kidney tissue, human placenta tissue, human rectal cancer tissue, mouse colon tissue, mouse pancreas tissue, mouse stomach tissue, rat kidney tissue, rat stomach tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Recommended Dilutions — Western Blot (WB) | WB : 1:1000-1:8000 |
| Recommended Dilutions — Immunohistochemistry (IHC) | IHC : 1:20-1:200 |
| Positive WB detected in | HeLa cells, PC-3 cells |
| Positive IHC detected in | human prostate hyperplasia tissue, human kidney tissue, human placenta tissue, human rectal cancer tissue, mouse colon tissue, mouse pancreas tissue, mouse stomach tissue, rat kidney tissue, rat stomach tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Western Blot (WB) | WB : 1:1000-1:8000 |
| Immunohistochemistry (IHC) | IHC : 1:20-1:200 |
| Tested Reactivity | human, mouse, rat |
| Cited Reactivity | human |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | CatNo: Ag8145 Product name: Recombinant human LZTS2 protein Source: e coli. -derived, PGEX-4T Tag: GST Domain: 319-669 aa of BC006212 Sequence: PSDEALLHCVLEGKLRDREAELQQLRDSLDENEATMCQAYEERQRHWQREREALREDCAAQAQRAQRAQQLLQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWEVCQKSGEISLLKQQLKESQAELVQKGSELVALRVALREARATLRVSEGRARGLQEAARARELELEACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESDEAKVQRAAAGVGGSLRAQVERLRVELQRERRRGEEQRDSFEGERLAWQAEKEQVIRYQKQLQHNYIQMYRRNRQLEQELQQLSLELEARELADLGLAEQAPCICLEEITATEI Predict reactive species |
| Full Name | leucine zipper, putative tumor suppressor 2 |
| Calculated Molecular Weight | 73 kDa |
| Observed Molecular Weight | 70-80 kDa |
| GenBank Accession Number | BC006212 |
| Gene Symbol | LZTS2 |
| Gene ID (NCBI) | 84445 |
| RRID | AB_2878166 |
| Conjugate | Unconjugated |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | Q9BRK4 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA. |
| IHC protocol for LZTS2 antibody 15677-1-AP | Download protocol |
| WB protocol for LZTS2 antibody 15677-1-AP | Download protocol |
| human | WB Biochem Pharmacol EBV-encoded miRNAs BHRF1-1 and BART2-5p aggravate post- transplant lymphoproliferative disorder via LZTS2-PI3K-AKT axis Authors - Hao Ji View Article |
| Citations | 12 |
| Dilutions | WB : 1:1000-1:8000 IHC : 1:20-1:200 |
| Isotype | IgG |
| Clonality | Polyclonal |
| Clone Number | - |
| Conjugation | Unconjugated |
LZTS2, also named as KIAA1813 and LAPSER1, is a novel b-Catenin-interacting protein and it regulates the nuclear export of b-Catenin. LZTS2 is a negative regulator of katanin-mediated microtubule severing and release from the centrosome. It is required for central spindle formation and the completion of cytokinesis. Protocols Product Specific Protocols IHC protocol for LZTS2 antibody 15677-1-AP Download protocol WB protocol for LZTS2 antibody 15677-1-AP Download protocol Standard Protocols Click here to view our Standard Protocols
Publications
- Proximity proteomics identifies PAK4 as a component of Afadin-Nectin junctions.
Journal: Nat Commun | Authors: Yohendran Baskaran | Application: IF - RRP15 deficiency induces ribosome stress to inhibit colorectal cancer proliferation and metastasis via LZTS2-mediated β-catenin suppression
Journal: Cell Death Dis | Authors: Zhixiong Dong | Species: human | Application: WB - SPOP and HAUSP bidirectionally regulate LZTS2 ubiquitination to modulate the Wnt pathway.
Journal: Cell Death Dis | Authors: Yanran Deng KD Validated | Species: human | Application: WB,IP,CoIP - LZTS2 inhibits PI3K/AKT activation and radioresistance in nasopharyngeal carcinoma by interacting with p85.
Journal: Cancer Lett | Authors: Shuangbing Xu KD Validated | Species: human | Application: WB - β-Trcp and CK1δ-mediated degradation of LZTS2 activates PI3K/AKT signaling to drive tumorigenesis and metastasis in hepatocellular carcinoma.
Journal: Oncogene | Authors: Yanwei Lu KD Validated | Species: human | Application: WB,IP - EBV-encoded miRNAs BHRF1-1 and BART2-5p aggravate post- transplant lymphoproliferative disorder via LZTS2-PI3K-AKT axis
Journal: Biochem Pharmacol | Authors: Hao Ji | Species: human | Application: WB
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