RON/MST1R Polyclonal antibody 11053-1-AP proteintech
$149.00
In stock
SKU
11053-1-AP
| Catalog Number | 11053-1-AP |
| Synonyms | MST1R, CD136, CDw136, EC:2.7.10.1, Macrophage-stimulating protein receptor |
| Host | Rabbit |
| Reactivity | human, mouse, rat |
| Form | Liquid |
| Formulation | PBS, Azide, Glycerol |
| Applications | WB, IHC, ELISA |
| Host / Isotype | Rabbit / IgG |
| Tested Applications — Positive WB detected in | mouse lung tissue, BxPC-3 cells |
| Tested Applications — Positive IHC detected in | human lung cancer tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Recommended Dilutions — Western Blot (WB) | WB : 1:500-1:1000 |
| Recommended Dilutions — Immunohistochemistry (IHC) | IHC : 1:50-1:500 |
| Positive WB detected in | mouse lung tissue, BxPC-3 cells |
| Positive IHC detected in | human lung cancer tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Western Blot (WB) | WB : 1:500-1:1000 |
| Immunohistochemistry (IHC) | IHC : 1:50-1:500 |
| Tested Reactivity | human, mouse, rat |
| Cited Reactivity | human, mouse |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | CatNo: Ag1537 Product name: Recombinant human RON, MST1R protein Source: e coli. -derived, PGEX-4T Tag: GST Domain: 1038-1332 aa of BQ936677 NM_002447 Sequence: ASFSDSEDESCVPLLRKESIQLRDLDSALLAEVKDVLIPHERVVTHSDRVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQQVEAFLREGLLMRGLNHPNVLALIGIMLPPEGLPHVLLPYMCHGDLLQFIRSPQRNPTVKDLISFGLQVARGMEYLAEQKFVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWMALESLQTYRFTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCPDSLYQVMQQCWEADPAVRP Predict reactive species |
| Full Name | macrophage stimulating 1 receptor (c-met-related tyrosine kinase) |
| Calculated Molecular Weight | 152 kDa |
| Observed Molecular Weight | 140 kDa |
| GenBank Accession Number | BQ936677 NM_002447 |
| Gene Symbol | RON |
| Gene ID (NCBI) | 4486 |
| RRID | AB_874180 |
| Conjugate | Unconjugated |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | Q04912 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA. |
| IHC protocol for RON/MST1R antibody 11053-1-AP | Download protocol |
| WB protocol for RON/MST1R antibody 11053-1-AP | Download protocol |
| mouse | WB Mol Ther Oncolytics RUNX1/EGFR pathway contributes to STAT3 activation and tumor growth caused by hyperactivated mTORC1. Authors - Wei Lin View Article |
| human | WB Theranostics Development of dual aptamers-functionalized c-MET PROTAC degraders for targeted therapy of osteosarcoma Authors - Xuekun Fu View Article |
| Citations | 2 |
| Dilutions | WB : 1:500-1:1000 IHC : 1:50-1:500 |
| Isotype | IgG |
| Clonality | Polyclonal |
| Clone Number | - |
| Conjugation | Unconjugated |
RON (also referred to as MST1R, or CD136) is a receptor tyrosine kinase that belongs to the MET proto-oncogene family. The precursor RON is produced as a glycosylated, single chain that is cleaved into a 185-kDa heterodimer of α (35 kDa) and β (150 kDa) subunits connected by a disulfide bond (PMID: 8062829). It is activated upon binding to its ligand, macrophage-stimulating protein (MSP, also known as MST1 and HGFL). RON signalling is essential for embryonic development and regulates many physiological processes including cell survival, migration and differentiation. Protocols Product Specific Protocols IHC protocol for RON/MST1R antibody 11053-1-AP Download protocol WB protocol for RON/MST1R antibody 11053-1-AP Download protocol Standard Protocols Click here to view our Standard Protocols
Publications
- RUNX1/EGFR pathway contributes to STAT3 activation and tumor growth caused by hyperactivated mTORC1.
Journal: Mol Ther Oncolytics | Authors: Wei Lin | Species: mouse | Application: WB - Development of dual aptamers-functionalized c-MET PROTAC degraders for targeted therapy of osteosarcoma
Journal: Theranostics | Authors: Xuekun Fu | Species: human | Application: WB
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