Mesothelin Recombinant monoclonal antibody, PBS Only 83744-7-PBS proteintech
$699.00
In stock
SKU
83744-7-PBS
| Catalog Number | 83744-7-PBS |
| Synonyms | MSLN, CAK1, CAK1 antigen, Megakaryocyte-potentiating factor, Mesothelin, cleaved form |
| Host | Rabbit |
| Reactivity | human |
| Form | Liquid |
| Formulation | PBS Only |
| Applications | WB, Indirect ELISA |
| Host / Isotype | Rabbit / IgG |
| Tested Reactivity | human |
| Class | Recombinant |
| Type | Antibody |
| Immunogen | DNA Predict reactive species |
| Full Name | mesothelin |
| Calculated Molecular Weight | 69KD |
| Observed Molecular Weight | 40-45 kDa, 69 kDa |
| GenBank Accession Number | NM_005823 |
| Gene Symbol | MSLN |
| Gene ID (NCBI) | 10232 |
| Conjugate | Unconjugated |
| Purification Method | Protein A purification |
| UNIPROT ID | Q13421 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
| Citations | - |
| Isotype | IgG |
| Clonality | Recombinant |
| Clone Number | 252795E5 |
| Conjugation | Unconjugated |
Mesothelin (MSLN) is a 40kDa GPI-anchored surface glycoprotein that is expressed on pleural and peritoneal mesothelial cells, but not in other non-neoplastic tissues. The mesothelin gene encodes a 69-71kDa precursor protein that is processed to a 40kDa membrane-bound protein termed mesothelin and a 31kDa shed fragment called megakaryocyte-potentiating factor (MPF) that is released from the cell. Mesothelin is a tumor differentiation antigen present at low levels on a restricted set of normal adult tissues (e.g. mesothelium), and is expressed at high levels in mesotheliomas, as well as ovarian, pancreatic, and lung cancers. Mesothelin may be a new target for immunotherapy (PMID: 20922056, 18691948, 15217923).
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