OTUD5 Polyclonal antibody 21002-1-AP proteintech
$149.00
In stock
SKU
21002-1-AP
| Catalog Number | 21002-1-AP |
| Synonyms | DUBA, EC:3.4.19.12, OTU domain-containing protein 5, OTUD 5 |
| Host | Rabbit |
| Reactivity | human, mouse, rat |
| Form | Liquid |
| Formulation | PBS, Azide, Glycerol |
| Applications | WB, IF/ICC, IP, CoIP, ELISA |
| Applications | WB, IF/ICC, ELISA |
| Host / Isotype | Rabbit / IgG |
| Tested Applications — Positive WB detected in | HEK-293T cells, HEK-293 cells, HeLa cells, Jurkat cells, K-562 cells, NIH/3T3 cells, C6 cells |
| Tested Applications — Positive IF/ICC detected in | A431 cells |
| Recommended Dilutions — Western Blot (WB) | WB : 1:500-1:3000 |
| Recommended Dilutions — Immunofluorescence (IF)/ICC | IF/ICC : 1:50-1:500 |
| Positive WB detected in | HEK-293T cells, HEK-293 cells, HeLa cells, Jurkat cells, K-562 cells, NIH/3T3 cells, C6 cells |
| Positive IF/ICC detected in | A431 cells |
| Western Blot (WB) | WB : 1:500-1:3000 |
| Immunofluorescence (IF)/ICC | IF/ICC : 1:50-1:500 |
| Tested Reactivity | human, mouse, rat |
| Cited Reactivity | human, mouse |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | CatNo: Ag15190 Product name: Recombinant human OTUD5 protein Source: e coli. -derived, PGEX-4T Tag: GST Domain: 202-561 aa of BC028225 Sequence: WFEKALRDKKGFIIKQMKEDGACLFRAVADQVYGDQDMHEVVRKHCMDYLMKNADYFSNYVTEDFTTYINRKRKNNCHGNHIEMQAMAEMYNRPVEVYQYSTEPINTFHGIHQNEDEPIRVSYHRNIHYNSVVNPNKATIGVGLGLPSFKPGFAEQSLMKNAIKTSEESWIEQQMLEDKKRATDWEATNEAIEEQVARESYLQWLRDQEKQARQVRGPSQPRKASATCSSATAAASSGLEEWTSRSPRQRSSASSPEHPELHAELGMKPPSPGTVLALAKPPSPCAPGTSSQFSAGADRATSPLVSLYPALECRALIQQMSPSAFGLNDWDDDEILASVLAVSQQEYLDSMKKNKVPCRC Predict reactive species |
| Full Name | OTU domain containing 5 |
| Calculated Molecular Weight | 571 aa, 61 kDa |
| Observed Molecular Weight | 70-75 kDa |
| GenBank Accession Number | BC028225 |
| Gene Symbol | OTUD5 |
| Gene ID (NCBI) | 55593 |
| RRID | AB_2878788 |
| Conjugate | Unconjugated |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | Q96G74 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA. |
| IF protocol for OTUD5 antibody 21002-1-AP | Download protocol |
| WB protocol for OTUD5 antibody 21002-1-AP | Download protocol |
| mouse,human | WB,IF Tissue Cell OTUD5 enhances activation of multiple cell death pathways and hyperoxia-induced lung injury by stabilizing TRAF4 and activating the p38/JNK pathway Authors - Xia Gu KD Validated View Article |
| human | WB,IF Clin Transl Med p53 inhibits OTUD5 transcription to promote GPX4 degradation and induce ferroptosis in gastric cancer Authors - Junjing Zhang KD Validated View Article |
| mouse | WB,IF,CoIP Nat Commun Podocyte OTUD5 alleviates diabetic kidney disease through deubiquitinating TAK1 and reducing podocyte inflammation and injury Authors - Ying Zhao View Article |
| Citations | 12 |
| Dilutions | WB : 1:500-1:3000 IF/ICC : 1:50-1:500 |
| Isotype | IgG |
| Clonality | Polyclonal |
| Clone Number | - |
| Conjugation | Unconjugated |
The deubiquitinating enzyme OTUD5, also known as deubiquitinating enzyme A (DUBA), is a member of the deubiquitinating enzyme OTU family. By deubiquitinating other proteins, OTUD5 is an important regulator of several physiological processes, such as immune signaling and DNA damage responses. The dysregulation of these processes can increase the risk of associated diseases, including inflammation, cancer and genetic disorders. Protocols Product Specific Protocols IF protocol for OTUD5 antibody 21002-1-AP Download protocol WB protocol for OTUD5 antibody 21002-1-AP Download protocol Standard Protocols Click here to view our Standard Protocols
Publications
- OTUD5 promotes end-joining of deprotected telomeres by promoting ATM-dependent phosphorylation of KAP1S824
Journal: Nat Commun | Authors: Shiu Yeung Lam | Species: mouse,human | Application: WB,IP,IF - OTUD5 Protects Dopaminergic Neurons by Promoting the Degradation of α-Synuclein in Parkinson's Disease Model
Journal: Adv Sci (Weinh) | Authors: Xiaomeng Song | Species: mouse,human | Application: WB,IF - p53 inhibits OTUD5 transcription to promote GPX4 degradation and induce ferroptosis in gastric cancer
Journal: Clin Transl Med | Authors: Junjing Zhang KD Validated | Species: human | Application: WB,IF - USP11 exacerbates radiation induced pneumonitis by activating endothelial cell inflammatory response via OTUD5-STING signaling
Journal: Int J Radiat Oncol Biol Phys | Authors: Yiting Tang | Species: mouse,human | Application: WB - OTUD5 enhances activation of multiple cell death pathways and hyperoxia-induced lung injury by stabilizing TRAF4 and activating the p38/JNK pathway
Journal: Tissue Cell | Authors: Xia Gu KD Validated | Species: mouse,human | Application: WB,IF - Podocyte OTUD5 alleviates diabetic kidney disease through deubiquitinating TAK1 and reducing podocyte inflammation and injury
Journal: Nat Commun | Authors: Ying Zhao | Species: mouse | Application: WB,IF,CoIP - Proteasome activity maintains cell-type-specific gene expression.
Journal: Cell Rep | Authors: Xiuxiu Lu | Species: human | Application: WB - USP11 exacerbates radiation induced pneumonitis by activating endothelial cell inflammatory response via OTUD5-STING signaling
Journal: Int J Radiat Oncol Biol Phys | Authors: Yiting Tang | Species: mouse,human | Application: WB - Dapagliflozin suppressed gastric cancer growth via regulating OTUD5 mediated YAP1 deubiquitination
Journal: Eur J Pharmacol | Authors: Kaijie Ren | Species: human | Application: WB,IP - CacyBP promotes the development of lung adenocarcinoma by regulating OTUD5
Journal: Carcinogenesis | Authors: Mixue Bai | Species: human | Application: WB - OTUD5 enhances activation of multiple cell death pathways and hyperoxia-induced lung injury by stabilizing TRAF4 and activating the p38/JNK pathway
Journal: Tissue Cell | Authors: Xia Gu | Species: mouse,human | Application: WB,IF - Hypoxia-induced proteasomal degradation of DBC1 by SIAH2 in breast cancer progression
Journal: Elife | Authors: Qiangqiang Liu | Species: human | Application: WB
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