PATZ1 Polyclonal antibody 26225-1-AP proteintech
$149.00
In stock
SKU
26225-1-AP
| Catalog Number | 26225-1-AP |
| Synonyms | MAZR, PATZ, POZ-, AT hook-, and zinc finger-containing protein 1, Protein kinase A RI subunit alpha-associated protein, RIAZ |
| Host | Rabbit |
| Reactivity | human, mouse |
| Form | Liquid |
| Formulation | PBS, Azide, Glycerol |
| Applications | WB, IHC, ChIP, ELISA |
| Applications | WB, ELISA |
| Host / Isotype | Rabbit / IgG |
| Tested Applications — Positive WB detected in | mouse spleen tissue, Raji cells |
| Recommended Dilutions — Western Blot (WB) | WB : 1:500-1:2000 |
| Positive WB detected in | mouse spleen tissue, Raji cells |
| Western Blot (WB) | WB : 1:500-1:2000 |
| Tested Reactivity | human, mouse |
| Cited Reactivity | human, mouse |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | CatNo: Ag23912 Product name: Recombinant human PATZ1 protein Source: e coli. -derived, PET28a Tag: 6*His Domain: 1-350 aa of BC021091 Sequence: MERVNDASCGPSGCYTYQVSRHSTEMLHNLNQQRKNGGRFCDVLLRVGDESFPAHRAVLAACSEYFESVFSAQLGDGGAADGGPADVGGATAAPGGGAGGSRELEMHTISSKVFGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIEICQEVIKQSNVQILVPPARADIMLFRPPGTSDLGFPLDMTNGAALAANSNGIAGSMQPEEEAARAAGAAIAGQASLPVLPGVDRLPMVAGPLSPQLLTSPFPSVASSAPPLTGKRGRGRPRKANLLDSMFGSPGGLREAGILPCGLCGKVFTDANRLRQHEAQHGVTSLQLGYIDLPPPRLGENGLPISEDPDGPRKRSR Predict reactive species |
| Full Name | POZ (BTB) and AT hook containing zinc finger 1 |
| Observed Molecular Weight | 70-74 kDa |
| GenBank Accession Number | BC021091 |
| Gene Symbol | PATZ1 |
| Gene ID (NCBI) | 23598 |
| RRID | AB_2880432 |
| Conjugate | Unconjugated |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | Q9HBE1 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA. |
| WB protocol for PATZ1 antibody 26225-1-AP | Download protocol |
| human | WB,IHC Adv Sci (Weinh) Dysregulation of the PATZ1/CTCF Balance Silences ZBTB20 to Drive Melanoma Progression. Authors - Chaowei Deng View Article |
| mouse | WB,IHC,ChIP Ecotoxicol Environ Saf GABARAPL1 is essential for ACR-induced autophagic cell death of mouse Leydig cells Authors - Jiahui Meng KD Validated View Article |
| Citations | 4 |
| Dilutions | WB : 1:500-1:2000 |
| Isotype | IgG |
| Clonality | Polyclonal |
| Clone Number | - |
| Conjugation | Unconjugated |
PATZ1 (POZ/BTB and AT-hook containing Zinc finger protein 1) is an important multifunctional transcriptional regulator. Its protein structure is distinctive, containing a POZ/BTB domain (which mediates protein-protein interactions and transcriptional repression) and an AT-hook motif (which binds to AT-rich DNA sequences), as well as multiple C2H2-type zinc finger domains (responsible for sequence-specific DNA binding). PATZ1 plays a "double-edged sword" role in regulating gene expression, capable of either activating or repressing target gene transcription depending on the co-regulators it interacts with and the cellular context. It plays a critical role in embryonic development and in the maintenance of stem cell pluripotency and differentiation. In recent years, its dual role in cancer has garnered significant attention. In various tumors (such as glioma, sarcoma, and colorectal cancer), PATZ1 can function as either an oncogene or a tumor suppressor depending on the context, participating in tumorigenesis and progression by influencing pathways such as the cell cycle, apoptosis, and the DNA damage response. Protocols Product Specific Protocols WB protocol for PATZ1 antibody 26225-1-AP Download protocol Standard Protocols Click here to view our Standard Protocols
Publications
- POZ/BTB and AT-Hook-Containing Zinc Finger Protein 1 (PATZ1) Suppresses Progression of Ovarian Cancer and Serves as an Independent Prognosis Factor.
Journal: Med Sci Monit | Authors: Cuihong Zhao | Species: human | Application: WB,IHC - GABARAPL1 is essential for ACR-induced autophagic cell death of mouse Leydig cells
Journal: Ecotoxicol Environ Saf | Authors: Jiahui Meng KD Validated | Species: mouse | Application: WB,IHC,ChIP - Dysregulation of the PATZ1/CTCF Balance Silences ZBTB20 to Drive Melanoma Progression.
Journal: Adv Sci (Weinh) | Authors: Chaowei Deng | Species: human | Application: WB,IHC - PATZ1 condensation adjacent to PML nuclear bodies suppresses HBoV transcription as an intrinsic antiviral defense.
Journal: Cell Rep | Authors: Chuchu Tian
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