Cardinal Red™ Anti-Human PD-1/CD279 (J110) CR-65119 proteintech
$175.00
In stock
SKU
CR-65119
| Catalog Number | CR-65119 |
| Synonyms | CD279, PD1, PD-1, hPD 1, hPD l |
| Host | Mouse |
| Reactivity | human |
| Form | Liquid |
| Formulation | PBS, Azide, BSA |
| Applications | FC |
| Host / Isotype | Mouse / IgG1 |
| Tested Applications — Positive FC detected in | PHA treated human PBMCs |
| Positive FC detected in | PHA treated human PBMCs |
| Flow Cytometry (FC) | FC : 5 ul per 10^6 cells in 100 μl suspension |
| Tested Reactivity | human |
| Class | Monoclonal |
| Type | Antibody |
| Immunogen | N/A Predict reactive species |
| Full Name | programmed cell death 1 |
| Calculated Molecular Weight | 288 aa, 32 kDa |
| GenBank Accession Number | BC074740 |
| Gene Symbol | PD-1 |
| Gene ID (NCBI) | 5133 |
| RRID | AB_3673832 |
| Conjugate | Cardinal Red™ Fluorescent Dye |
| Excitation/Emission Maxima Wavelengths | 592 nm / 611 nm |
| Excitation Laser | Yellow-Green Laser (561 nm) |
| Purification Method | Affinity purification |
| UNIPROT ID | Q15116 |
| Storage Buffer | PBS with 0.09% sodium azide and 0.5% BSA, pH 7.3. |
| Storage Conditions | Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment. |
| FC protocol for Cardinal Red™ PD-1/CD279 antibody CR-65119 | Download protocol |
| Citations | - |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Clone Number | J110 |
| Conjugation | Cardinal Red™ |
Programmed cell death 1 (PD-1, also known as CD279) is an immunoinhibitory receptor that belongs to the CD28/CTLA-4 subfamily of the Ig superfamily. It is a 288 amino acid (aa) type I transmembrane protein composed of one Ig superfamily domain, a stalk, a transmembrane domain, and an intracellular domain containing an immunoreceptor tyrosine-based inhibitory motif (ITIM) as well as an immunoreceptor tyrosine-based switch motif (ITSM) (PMID: 18173375). PD-1 is expressed during thymic development and is induced in a variety of hematopoietic cells in the periphery by antigen receptor signaling and cytokines (PMID: 20636820). Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation, cytokine production, and cytolytic function (PMID: 19426218). It is critical for the regulation of T cell function during immunity and tolerance. Blockade of PD-1 can overcome immune resistance and also has been shown to have antitumor activity (PMID: 22658127; 23169436). Protocols Product Specific Protocols FC protocol for Cardinal Red™ PD-1/CD279 antibody CR-65119 Download protocol Standard Protocols Click here to view our Standard Protocols
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