PTPRH Monoclonal antibody 68635-1-Ig proteintech
$149.00
In stock
SKU
68635-1-Ig
| Catalog Number | 68635-1-Ig |
| Synonyms | 3C6E8, R PTP H, SAP 1, SAP1 |
| Host | Mouse |
| Reactivity | human, pig |
| Form | Liquid |
| Formulation | PBS, Azide, Glycerol |
| Applications | WB, IF/ICC, ELISA |
| Host / Isotype | Mouse / IgG1 |
| Tested Applications — Positive WB detected in | pig spleen tissue, A431 cells |
| Tested Applications — Positive IF/ICC detected in | HT-29 cells |
| Recommended Dilutions — Western Blot (WB) | WB : 1:5000-1:50000 |
| Recommended Dilutions — Immunofluorescence (IF)/ICC | IF/ICC : 1:250-1:1000 |
| Positive WB detected in | pig spleen tissue, A431 cells |
| Positive IF/ICC detected in | HT-29 cells |
| Western Blot (WB) | WB : 1:5000-1:50000 |
| Immunofluorescence (IF)/ICC | IF/ICC : 1:250-1:1000 |
| Tested Reactivity | human, pig |
| Class | Monoclonal |
| Type | Antibody |
| Immunogen | CatNo: Ag17351 Product name: Recombinant human PTPRH protein Source: e coli. -derived, PET28a Tag: 6*His Domain: 378-727 aa of BC111716 Sequence: ETRNATTAPNPVRNLHMETQTNSSIALCWEVPDGPYPQDYTYWVEYTGDGGGTETRNTTNTSVTAERLEPGTLYTFSVWAEKNGARGSRQNVSISTVPNAVTSLSKQDWTNSTIALRWTAPQGPGQSSYSYWVSWVREGMTDPRTQSTSGTDITLKELEAGSLYHLTVWAERNEVRGYNSTLTAATAPNEVTDLQNETQTKNSVMLWWKAPGDPHSQLYVYWVQWASKGHPRRGQDPQANWVNQTSRTNETWYKVEALEPGTLYNFTVWAERNDVASSTQSLCASTYPDTVTITSCVSTSAGYGVNLIWSCPQGGYEAFELEVGGQRGSQDRSSCGEAVSVLGLGPARSY Predict reactive species |
| Full Name | protein tyrosine phosphatase, receptor type, H |
| Calculated Molecular Weight | 1115 aa, 122 kDa |
| Observed Molecular Weight | 200-250 kDa |
| GenBank Accession Number | BC111716 |
| Gene Symbol | PTPRH |
| Gene ID (NCBI) | 5794 |
| RRID | AB_3743311 |
| Conjugate | Unconjugated |
| Purification Method | Protein G purification |
| UNIPROT ID | Q9HD43 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA. |
| IF protocol for PTPRH antibody 68635-1-Ig | Download protocol |
| WB protocol for PTPRH antibody 68635-1-Ig | Download protocol |
| Citations | - |
| Dilutions | WB : 1:5000-1:50000 IF/ICC : 1:250-1:1000 |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Clone Number | 3C6E8 |
| Conjugation | Unconjugated |
PTPRH, also known as SAP-1 (Stomach Cancer-Associated Protein-Tyrosine Phosphatase-1), is a member of the protein tyrosine phosphatase (PTP) family. These enzymes regulate cellular signaling by dephosphorylating tyrosine residues on proteins, counterbalancing kinase activity (PMID: 11278335). PTPRH is classified as a receptor-type PTP, characterized by an extracellular domain, a transmembrane region, and intracellular catalytic domains. In colorectal, gastric, and hepatocellular cancers, PTPRH is often upregulated and linked to poor prognosis (PMID: 12101188). Paradoxically, it may suppress tumorigenesis in other contexts by stabilizing cell adhesion. Overexpression in certain cancers suggests utility as a diagnostic or prognostic marker. The molecular weight of PTPRH is 122 kDa, it is reported that it can form a dimer with a molecular weight of 210 kDa (PMID:15850787). It is also reported that 250kDa bands were detected in small intestine of mice.(PMID:19170756) Protocols Product Specific Protocols IF protocol for PTPRH antibody 68635-1-Ig Download protocol WB protocol for PTPRH antibody 68635-1-Ig Download protocol Standard Protocols Click here to view our Standard Protocols
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