Phospho-Estrogen Receptor α (Ser118) Recombinant monoclonal antibody, PBS Only 84564-6-PBS proteintech
$699.00
In stock
SKU
84564-6-PBS
| Catalog Number | 84564-6-PBS |
| Synonyms | Estrogen Receptor α (Ser118), p Estrogen Receptor α, p-ERS1, p-ERS1 (Ser118), p-Estrogen Receptor α |
| Host | Rabbit |
| Reactivity | human |
| Form | Liquid |
| Formulation | PBS Only |
| Applications | WB, IF/ICC, FC (Intra), IP, Indirect ELISA, ChIP-qPCR |
| Host / Isotype | Rabbit / IgG |
| Tested Reactivity | human |
| Class | Recombinant |
| Type | Antibody |
| Immunogen | Peptide Predict reactive species |
| Full Name | estrogen receptor 1 |
| Calculated Molecular Weight | 595 aa, 66 kDa |
| Observed Molecular Weight | 66 kDa |
| GenBank Accession Number | BC128573 |
| Gene Symbol | ER |
| Gene ID (NCBI) | 2099 |
| RRID | AB_3743587 |
| Conjugate | Unconjugated |
| Purification Method | Protein A purification |
| UNIPROT ID | P03372 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
| Citations | - |
| Isotype | IgG |
| Clonality | Recombinant |
| Clone Number | 250278F8 |
| Conjugation | Unconjugated |
Estrogen Receptor α (ERα, gene symbol ESR1) is a member of the nuclear-receptor superfamily that functions as a ligand-dependent transcription factor. Dependent upon cell and promoter context, ERα regulates transcription through its two activation domains, AF-1 and AF-2. AF-2 is contained within the LBD and becomes active upon E2 binding. AF-1 however, is activated by phosphorylation of ERα at several sites, most notably serine 118 (S118) and serine 167 (S167), sites that are regulated by multiple signaling pathways. (PMID: 25597633)
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