Phospho-STAT6 (Tyr641) Recombinant monoclonal antibody, PBS Only 86641-1-PBS proteintech
$699.00
In stock
SKU
86641-1-PBS
| Catalog Number | 86641-1-PBS |
| Synonyms | p STAT6 (Tyr641), Phospho STAT6, Phospho STAT6 (Tyr641), Phospho STAT6(Tyr641), Phospho-STAT6 |
| Host | Rabbit |
| Reactivity | human |
| Form | Liquid |
| Formulation | PBS Only |
| Applications | WB, IF/ICC, FC (Intra), Indirect ELISA |
| Host / Isotype | Rabbit / IgG |
| Tested Reactivity | human |
| Class | Recombinant |
| Type | Antibody |
| Immunogen | Peptide Predict reactive species |
| Full Name | signal transducer and activator of transcription 6, interleukin-4 induced |
| Calculated Molecular Weight | 100 kDa |
| Observed Molecular Weight | 110 kDa |
| GenBank Accession Number | BC005823 |
| Gene Symbol | STAT6 |
| Gene ID (NCBI) | 6778 |
| RRID | AB_3745023 |
| Conjugate | Unconjugated |
| Purification Method | Protein A purification |
| UNIPROT ID | P42226 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
| Citations | - |
| Isotype | IgG |
| Clonality | Recombinant |
| Clone Number | 250940C12 |
| Conjugation | Unconjugated |
STAT6, also named as Signal transducer and activator of transcription 6, is a 847 amino acid protein, which belongs to the transcription factor STAT family. p-STAT6(Tyr641) is a biomarker of Th2-high inflammation, targeted by IL-4Rα blockers (dupilumab) and JAK1/3 inhibitors. High p-STAT6 in TAMs correlates with M2 polarization and radioresistance, blocking IL-4 or JAK1/3 decreases Tyr641 phosphorylation and restores anti-tumor immunity. (PMID: 37474750)
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