Phospho-TSC2 (Ser1387) Recombinant monoclonal antibody 80553-2-RR proteintech
$149.00
In stock
SKU
80553-2-RR
| Catalog Number | 80553-2-RR |
| Synonyms | Phospho-Tuberin (Ser1387), Phospho-Tuberin/TSC2 (Ser1387), Phos-TSC2 (Ser1387), Phos-Tuberin (Ser1387), P-TSC2 (Ser1387) |
| Host | Rabbit |
| Reactivity | human, mouse |
| Form | Liquid |
| Formulation | PBS, Azide, Glycerol |
| Applications | WB, FC (Intra), ELISA |
| Host / Isotype | Rabbit / IgG |
| Tested Applications — Positive WB detected in | Calyculin A treated NIH/3T3 cells, NIH/3T3 cells |
| Tested Applications — Positive FC (Intra) detected in | Calyculin A treated HeLa cells |
| Recommended Dilutions — Western Blot (WB) | WB : 1:1000-1:4000 |
| Recommended Dilutions — Flow Cytometry (FC) (INTRA) | FC (INTRA) : 0.13 ug per 10^6 cells in a 100 µl suspension |
| Positive WB detected in | Calyculin A treated NIH/3T3 cells, NIH/3T3 cells |
| Positive FC (Intra) detected in | Calyculin A treated HeLa cells |
| Western Blot (WB) | WB : 1:1000-1:4000 |
| Flow Cytometry (FC) (INTRA) | FC (INTRA) : 0.13 ug per 10^6 cells in a 100 µl suspension |
| Tested Reactivity | human, mouse |
| Class | Recombinant |
| Type | Antibody |
| Immunogen | Peptide Predict reactive species |
| Full Name | tuberous sclerosis 2 |
| Calculated Molecular Weight | 1807 aa, 201 kDa |
| Observed Molecular Weight | 200 kDa |
| GenBank Accession Number | BC150300 |
| Gene Symbol | TSC2 |
| Gene ID (NCBI) | 7249 |
| RRID | AB_3743345 |
| Conjugate | Unconjugated |
| Purification Method | Protein A purification |
| UNIPROT ID | P49815 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA. |
| FC protocol for Phospho-TSC2 (Ser1387) antibody 80553-2-RR | Download protocol |
| WB protocol for Phospho-TSC2 (Ser1387) antibody 80553-2-RR | Download protocol |
| Citations | - |
| Dilutions | WB : 1:1000-1:4000 FC (INTRA) : 0.13 ug per 10^6 cells in a 100 µl suspension |
| Isotype | IgG |
| Clonality | Recombinant |
| Clone Number | 242665D1 |
| Conjugation | Unconjugated |
TSC2, also named as Tuberin, plays an essential role in the cellular energy response pathway. TSC2 forms a physical and functional complex with TSC1 that can inhibit the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. AMPK can phosphorylate and activate the Ser1387 site of TSC2.(PMID: 14651849, 12172553, PMID: 23244622) Protocols Product Specific Protocols FC protocol for Phospho-TSC2 (Ser1387) antibody 80553-2-RR Download protocol WB protocol for Phospho-TSC2 (Ser1387) antibody 80553-2-RR Download protocol Standard Protocols Click here to view our Standard Protocols
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