Phospho-TSC2 (Thr1462) Recombinant monoclonal antibody 80698-1-RR proteintech
$149.00
In stock
SKU
80698-1-RR
| Catalog Number | 80698-1-RR |
| Synonyms | p TSC2, p TSC2 (Thr1462), p TSC2 Thr1462, Phospho TSC2, Phospho TSC2 (Thr1462) |
| Host | Rabbit |
| Reactivity | human, mouse |
| Form | Liquid |
| Formulation | PBS, Azide, Glycerol |
| Applications | WB, ELISA |
| Host / Isotype | Rabbit / IgG |
| Tested Applications — Positive WB detected in | Calyculin A treated HEK-293 cells, Calyculin A treated NIH/3T3 cells |
| Recommended Dilutions — Western Blot (WB) | WB : 1:2000-1:10000 |
| Positive WB detected in | Calyculin A treated HEK-293 cells, Calyculin A treated NIH/3T3 cells |
| Western Blot (WB) | WB : 1:2000-1:10000 |
| Tested Reactivity | human, mouse |
| Class | Recombinant |
| Type | Antibody |
| Immunogen | Peptide Predict reactive species |
| Full Name | tuberous sclerosis 2 |
| Calculated Molecular Weight | 1807 aa, 201 kDa |
| Observed Molecular Weight | 200 kDa |
| GenBank Accession Number | BC150300 |
| Gene Symbol | TSC2 |
| Gene ID (NCBI) | 7249 |
| RRID | AB_3085354 |
| Conjugate | Unconjugated |
| Purification Method | Protein A purification |
| UNIPROT ID | P49815 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA. |
| WB protocol for Phospho-TSC2 (Thr1462) antibody 80698-1-RR | Download protocol |
| Citations | - |
| Dilutions | WB : 1:2000-1:10000 |
| Isotype | IgG |
| Clonality | Recombinant |
| Clone Number | 1L20 |
| Conjugation | Unconjugated |
TSC2, also named Tuberin, plays an essential role in the cellular energy response pathway. TSC2 forms a physical and functional complex with TSC1 that can inhibit the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. It has been reported that TSC2 can be phosphorylated at Thr1462 by Akt/PKB involved in stimulating cell growth and is activated by insulin. (PMID: 14651849, 12172553) Protocols Product Specific Protocols WB protocol for Phospho-TSC2 (Thr1462) antibody 80698-1-RR Download protocol Standard Protocols Click here to view our Standard Protocols
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