Polyglutamine Monoclonal antibody, PBS Only 65239-1-PBS proteintech
$699.00
In stock
SKU
65239-1-PBS
| Catalog Number | 65239-1-PBS |
| Synonyms | Glutamine repeats, polyQ |
| Host | Mouse |
| Reactivity | n/a |
| Form | Liquid |
| Formulation | PBS Only |
| Applications | WB, ELISA, Indirect ELISA |
| Host / Isotype | Mouse / IgG2b, kappa |
| Tested Reactivity | n/a |
| Class | Monoclonal |
| Type | Antibody |
| Immunogen | Recombinant protein Predict reactive species |
| Full Name | Polyglutamine |
| GenBank Accession Number | N/A |
| RRID | AB_3085031 |
| Conjugate | Unconjugated |
| Purification Method | Protein A purification |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
| Citations | - |
| Isotype | IgG2b, kappa |
| Clonality | Monoclonal |
| Clone Number | MW1 |
| Conjugation | Unconjugated |
Huntington's disease is a neurodegenerative disorder caused by the expansion of a polyglutamine (polyQ) repeat in the N-terminal portion of huntingtin protein to a length above 35-40 units (PMID: 26047735; 19507258). The mutational expansion of polyglutamine above a critical length causes a toxic gain of function in huntingtin and results in neuronal death. In the course of the disease, expanded huntingtin is proteolyzed, becomes abnormally folded, and accumulates in oligomers, fibrils, and microscopic inclusions (PMID: 25336039). The anti-polyglutamine (polyQ) antibody MW1 specifically binds the polyQ domain of huntingtin exon 1. On western blot, the MW1 clone strongly prefers to bind to the expanded polyQ repeat form of Htt, displaying no detectable binding to normal huntingtin (PMID: 11719267).
Reviews
Write Your Own Review
Related Products
Check items to add to the cart or
