REG3G Polyclonal antibody 33895-1-AP proteintech
$149.00
In stock
SKU
33895-1-AP
| Catalog Number | 33895-1-AP |
| Synonyms | Pancreatitis-associated protein 1B, Pancreatitis-associated protein IB, PAP IB, PAP1B, PAP-1B |
| Host | Rabbit |
| Reactivity | human, mouse |
| Form | Liquid |
| Formulation | PBS, Azide, Glycerol |
| Applications | WB, ELISA |
| Host / Isotype | Rabbit / IgG |
| Tested Applications — Positive WB detected in | mouse pancreas tissue |
| Recommended Dilutions — Western Blot (WB) | WB : 1:500-1:2000 |
| Positive WB detected in | mouse pancreas tissue |
| Western Blot (WB) | WB : 1:500-1:2000 |
| Tested Reactivity | human, mouse |
| Cited Reactivity | mouse |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | CatNo: Ag35686 Product name: Recombinant human REG3G protein Source: e coli. -derived, PGEX-4T Tag: GST Domain: 27-175 aa of BC103854 Sequence: EETQKELPSPRISCPKGSKAYGSPCYALFLSPKSWMDADLACQKRPSGKLVSVLSGAEGSFVSSLVRSISNSYSYIWIGLHDPTQGSEPDGDGWEWSSTDVMNYFAWEKNPSTILNPGHCGSLSRSTGFLKWKDYNCDAKLPYVCKFKD Predict reactive species |
| Full Name | regenerating islet-derived 3 gamma |
| Calculated Molecular Weight | 19 kDa |
| Observed Molecular Weight | 18 kDa |
| GenBank Accession Number | BC103854 |
| Gene Symbol | REG3G |
| Gene ID (NCBI) | 130120 |
| RRID | AB_3743105 |
| Conjugate | Unconjugated |
| Purification Method | Antigen affinity Purification |
| UNIPROT ID | Q6UW15 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA. |
| WB protocol for REG3G antibody 33895-1-AP | Download protocol |
| mouse | WB Curr Res Food Sci High-sugar and carrageenan-containing diets synergistically impair the intestinal mucosal barrier through the gut microbiota: in vitro and in vivo studies. Authors - Yuan Gao View Article |
| Citations | 1 |
| Dilutions | WB : 1:500-1:2000 |
| Isotype | IgG |
| Clonality | Polyclonal |
| Clone Number | - |
| Conjugation | Unconjugated |
REG3G (Regenerating Islet-Derived 3 Gamma) is a small intestinal C-type lectin-like antimicrobial peptide mainly secreted by Paneth cells. First identified in regenerating pancreas, it is now recognized as a key defender of the gut barrier: it kills Gram-positive bacteria, limits bacterial contact with the epithelium, and thus helps prevent systemic inflammation and metabolic disease. Beyond its antimicrobial role, REG3G acts as a gut-derived hormone that links the intestinal microbiome to host metabolism. Its expression is boosted by dietary fiber, beneficial bacteria, interleukin-22 (IL-22) and bariatric surgery, and it reciprocally improves glucose control, reduces hepatic steatosis, accelerates wound healing and protects pancreatic β-cells by activating the JAK2/STAT3 pathway . Conversely, chronic alcohol intake or dysbiosis lowers REG3G levels, weakening the gut barrier and promoting alcoholic liver disease. Protocols Product Specific Protocols WB protocol for REG3G antibody 33895-1-AP Download protocol Standard Protocols Click here to view our Standard Protocols
Publications
- High-sugar and carrageenan-containing diets synergistically impair the intestinal mucosal barrier through the gut microbiota: in vitro and in vivo studies.
Journal: Curr Res Food Sci | Authors: Yuan Gao | Species: mouse | Application: WB
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