SCN10A/Nav1.8 Polyclonal antibody 55334-1-AP proteintech
$149.00
In stock
SKU
55334-1-AP
| Catalog Number | 55334-1-AP |
| Synonyms | SCN10A, hPN3, Nav1.8, PN3, SNS |
| Host | Rabbit |
| Reactivity | human, mouse, rat |
| Form | Liquid |
| Formulation | PBS, Azide, Glycerol |
| Applications | IHC, IF/ICC, FC (Intra), ELISA |
| Host / Isotype | Rabbit / IgG |
| Tested Applications — Positive IHC detected in | mouse brain tissue, rat Ischiadic nerve tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Tested Applications — Positive IF/ICC detected in | SH-SY5Y cells |
| Tested Applications — Positive FC (Intra) detected in | HeLa cells |
| Recommended Dilutions — Immunohistochemistry (IHC) | IHC : 1:200-1:800 |
| Recommended Dilutions — Immunofluorescence (IF)/ICC | IF/ICC : 1:10-1:100 |
| Recommended Dilutions — Flow Cytometry (FC) (INTRA) | FC (INTRA) : 0.40 ug per 10^6 cells in a 100 µl suspension |
| Positive IHC detected in | mouse brain tissue, rat Ischiadic nerve tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Positive IF/ICC detected in | SH-SY5Y cells |
| Positive FC (Intra) detected in | HeLa cells |
| Immunohistochemistry (IHC) | IHC : 1:200-1:800 |
| Immunofluorescence (IF)/ICC | IF/ICC : 1:10-1:100 |
| Flow Cytometry (FC) (INTRA) | FC (INTRA) : 0.40 ug per 10^6 cells in a 100 µl suspension |
| Tested Reactivity | human, mouse, rat |
| Cited Reactivity | human |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide Predict reactive species |
| Full Name | sodium channel, voltage-gated, type X, alpha subunit |
| Calculated Molecular Weight | 221 kDa |
| GenBank Accession Number | NM_006514 |
| Gene Symbol | SCN10A |
| Gene ID (NCBI) | 6336 |
| RRID | AB_2881309 |
| Conjugate | Unconjugated |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | Q9Y5Y9 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA. |
| FC protocol for SCN10A/Nav1.8 antibody 55334-1-AP | Download protocol |
| IF protocol for SCN10A/Nav1.8 antibody 55334-1-AP | Download protocol |
| IHC protocol for SCN10A/Nav1.8 antibody 55334-1-AP | Download protocol |
| human | IF J Biomed Sci Microglial MARCO facilitates Varicella zoster virus uptake and triggers TLR2-mediated neuroinflammation. Authors - Ji-Soo Lim View Article |
| Citations | 1 |
| Dilutions | IHC : 1:200-1:800 IF/ICC : 1:10-1:100 FC (INTRA) : 0.40 ug per 10^6 cells in a 100 µl suspension |
| Isotype | IgG |
| Clonality | Polyclonal |
| Clone Number | - |
| Conjugation | Unconjugated |
Sodium channel protein type 10 subunit alpha (SCN10A, also known as Nav1.8) is predominantly expressed in neurons of the dorsal root ganglion (DRG) and trigeminal ganglion (PMID: 8538791; 9169448). Nav1.8 markedly modulates nociceptor excitability, and thereby participates in pain‑processing mechanisms (PMID: 20367448; 11495938). Furthermore, functional SCN10A/Nav1.8 has been detected in intracardiac neurons, revealing a previously unrecognized function of this neuronal sodium channel in the modulation of cardiac electrical activity (PMID: 22723301). Protocols Product Specific Protocols FC protocol for SCN10A/Nav1.8 antibody 55334-1-AP Download protocol IF protocol for SCN10A/Nav1.8 antibody 55334-1-AP Download protocol IHC protocol for SCN10A/Nav1.8 antibody 55334-1-AP Download protocol Standard Protocols Click here to view our Standard Protocols
Publications
- Microglial MARCO facilitates Varicella zoster virus uptake and triggers TLR2-mediated neuroinflammation.
Journal: J Biomed Sci | Authors: Ji-Soo Lim | Species: human | Application: IF
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