SEC61 Alpha Polyclonal antibody 24935-1-AP proteintech
$149.00
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SKU
24935-1-AP
| Catalog Number | 24935-1-AP |
| Synonyms | SEC61A2, Sec61 alpha-2, Protein transport protein Sec61 subunit alpha isoform 2 |
| Host | Rabbit |
| Reactivity | human, mouse and More (1) |
| Reactivity | human, mouse, rat |
| Form | Liquid |
| Formulation | PBS, Azide, Glycerol |
| Applications | WB, IF, CoIP, ELISA |
| Applications | WB, ELISA |
| Host / Isotype | Rabbit / IgG |
| Tested Applications — Positive WB detected in | mouse brain tissue, HEK-293 cells, U2OS cells, mouse liver tissue |
| Recommended Dilutions — Western Blot (WB) | WB : 1:500-1:1000 |
| Positive WB detected in | mouse brain tissue, HEK-293 cells, U2OS cells, mouse liver tissue |
| Western Blot (WB) | WB : 1:500-1:1000 |
| Tested Reactivity | human, mouse |
| Cited Reactivity | human, rat |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | CatNo: Ag20779 Product name: Recombinant human SEC61A2 protein Source: e coli. -derived, PET30a Tag: 6*His Domain: 190-418 aa of BC026179 Sequence: TIVWKAFSPTTINTGRGTEFEGAVIALFHLLATRTDKVRALREAFYRQNLPNLMNLIATVFVFAVVIYFQGFRVDLPIKSARYRGQYSSYPIKLFYTSNIPIILQSALVSNLYVISQMLSVRFSGNFLVNLLGQWADVSGGGPARSYPVGGLCYYLSPPESMGAIFEDPVHVVVYIIFMLGSCAFFSKTWIEVSGSSAKDVAKQLKEQQMVMRGHRDTSMVHELNSARA Predict reactive species |
| Full Name | Sec61 alpha 2 subunit (S. cerevisiae) |
| Calculated Molecular Weight | 52 kDa |
| Observed Molecular Weight | 52 kDa |
| GenBank Accession Number | BC026179 |
| Gene Symbol | SEC61 Alpha |
| Gene ID (NCBI) | 55176 |
| RRID | AB_2879807 |
| Conjugate | Unconjugated |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | Q9H9S3 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA. |
| WB protocol for SEC61 Alpha antibody 24935-1-AP | Download protocol |
| human | IF Adv Sci (Weinh) Activation of Lysosomal Retrograde Transport Triggers TPC1-IP3R1 Ca2+ Crosstalk at Lysosome-ER MCSs Leading to Lethal Depleting of ER Calcium Authors - Meng-Yuan Zhu View Article |
| rat | CoIP iScience The endoplasmic reticulum membrane complex promotes proteostasis of GABAA receptors Authors - Angela L. Whittsette View Article |
| Boyan (Verified Customer) (12-16-2021) | This antibody recognized a band around 60 kd, but it also recognized a similar band in solo loading buffer. Applications: Western Blot |
| Citations | 3 |
| Dilutions | WB : 1:500-1:1000 |
| Isotype | IgG |
| Clonality | Polyclonal |
| Clone Number | - |
| Conjugation | Unconjugated |
The SEC61 complex is a major component of the endoplasmic reticulum (ER) translocation site (PMID: 7720858). This complex is composed of three subunits: SEC61alpha, SEC61beta and SEC61gamma. SEC61alpha is a polytopic integral membrane protein. It is a core component of the ER translocation complex, playing a crucial role in the insertion of secretory and membrane polypeptides into the ER (PMID: 9512475). Protocols Product Specific Protocols WB protocol for SEC61 Alpha antibody 24935-1-AP Download protocol Standard Protocols Click here to view our Standard Protocols
Publications
- Oncoprotein SND1 hijacks nascent MHC-I heavy chain to ER-associated degradation, leading to impaired CD8+ T cell response in tumor.
Journal: Sci Adv | Authors: Yuan Wang | Species: human | Application: IF - The endoplasmic reticulum membrane complex promotes proteostasis of GABAA receptors
Journal: iScience | Authors: Angela L. Whittsette | Species: rat | Application: CoIP - Activation of Lysosomal Retrograde Transport Triggers TPC1-IP3R1 Ca2+ Crosstalk at Lysosome-ER MCSs Leading to Lethal Depleting of ER Calcium
Journal: Adv Sci (Weinh) | Authors: Meng-Yuan Zhu | Species: human | Application: IF
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