SEL1L Recombinant monoclonal antibody 84317-7-RR proteintech
$149.00
In stock
SKU
84317-7-RR
| Catalog Number | 84317-7-RR |
| Synonyms | 241594G2, Protein sel 1 homolog 1, Protein sel-1 homolog 1, Sel 1L, Sel-1L |
| Host | Rabbit |
| Reactivity | human, mouse, rat |
| Form | Liquid |
| Formulation | PBS, Azide, Glycerol |
| Applications | WB, FC (Intra), ELISA |
| Host / Isotype | Rabbit / IgG |
| Tested Applications — Positive WB detected in | NIH/3T3 cells, HepG2 cells, MCF-7 cells, BxPC-3 cells, U-87 MG cells, mouse kidney tissue, rat liver tissue |
| Tested Applications — Positive FC (Intra) detected in | MCF-7 cells |
| Recommended Dilutions — Western Blot (WB) | WB : 1:2000-1:6000 |
| Recommended Dilutions — Flow Cytometry (FC) (INTRA) | FC (INTRA) : 0.25 ug per 10^6 cells in a 100 µl suspension |
| Positive WB detected in | NIH/3T3 cells, HepG2 cells, MCF-7 cells, BxPC-3 cells, U-87 MG cells, mouse kidney tissue, rat liver tissue |
| Positive FC (Intra) detected in | MCF-7 cells |
| Western Blot (WB) | WB : 1:2000-1:6000 |
| Flow Cytometry (FC) (INTRA) | FC (INTRA) : 0.25 ug per 10^6 cells in a 100 µl suspension |
| Tested Reactivity | human, mouse, rat |
| Cited Reactivity | mouse |
| Class | Recombinant |
| Type | Antibody |
| Immunogen | CatNo: Ag32178 Product name: Recombinant human SEL1L protein Source: e coli. -derived, PGEX-4T Tag: GST Domain: 22-225 aa of NM_005065 Sequence: SSDEEGSQDESLDSKTTLTSDESVKDHTTAGRVVAGQIFLDSEESELESSIQEEEDSLKSQEGESVTEDISFLESPNPENKDYEEPKKVRKPALTAIEGTAHGEPCHFPFLFLDKEYDECTSDGREDGRLWCATTYDYKADEKWGFCETEEEAAKRRQMQEAEMMYQTGMKILNGSNKKSQKREAYRYLQKAASMNHTKALERV Predict reactive species |
| Full Name | sel-1 suppressor of lin-12-like (C. elegans) |
| Calculated Molecular Weight | 89 kDa |
| Observed Molecular Weight | 89 kDa |
| GenBank Accession Number | NM_005065 |
| Gene Symbol | SEL1L |
| Gene ID (NCBI) | 6400 |
| RRID | AB_3671858 |
| Conjugate | Unconjugated |
| Purification Method | Protein A purfication |
| UNIPROT ID | Q9UBV2 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA. |
| FC protocol for SEL1L antibody 84317-7-RR | Download protocol |
| WB protocol for SEL1L antibody 84317-7-RR | Download protocol |
| mouse | WB Bone Disease-associated TNFRSF11B variants differentially disrupt osteoprotegerin secretion and function. Authors - Reina Suzuki KD Validated View Article |
| Citations | 1 |
| Dilutions | WB : 1:2000-1:6000 FC (INTRA) : 0.25 ug per 10^6 cells in a 100 µl suspension |
| Isotype | IgG |
| Clonality | Recombinant |
| Clone Number | 241594G2 |
| Conjugation | Unconjugated |
SEL1L (Suppressor Enhancer Lin-12 Like) is an endoplasmic reticulum-resident transmembrane protein that plays a critical role in collagen metabolism. It has been identified as an intracellular rheostat controlling collagen turnover, which is the balance between collagen synthesis and degradation. The protein's luminal face contains a Fibronectin-2 (FN2) domain, which is known to bind collagen. SEL1L functions as a sensor of collagen biosynthesis and is necessary for the upregulation of MRC2 (mannose receptor, C-type 2), a collagen endocytic receptor that mediates the clearance of collagen. . Protocols Product Specific Protocols FC protocol for SEL1L antibody 84317-7-RR Download protocol WB protocol for SEL1L antibody 84317-7-RR Download protocol Standard Protocols Click here to view our Standard Protocols
Publications
- Disease-associated TNFRSF11B variants differentially disrupt osteoprotegerin secretion and function.
Journal: Bone | Authors: Reina Suzuki KD Validated | Species: mouse | Application: WB
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