Neuroserpin Polyclonal antibody 12558-1-AP proteintech
$149.00
In stock
SKU
12558-1-AP
| Catalog Number | 12558-1-AP |
| Synonyms | Serpin I1, PI-12, PI12, PI 12, Peptidase inhibitor 12 |
| Host | Rabbit |
| Reactivity | human, mouse, rat |
| Form | Liquid |
| Formulation | PBS, Azide, Glycerol |
| Applications | WB, IF-P, IP, ELISA |
| Host / Isotype | Rabbit / IgG |
| Tested Applications — Positive WB detected in | mouse brain tissue |
| Tested Applications — Positive IP detected in | rat brain tissue |
| Tested Applications — Positive IF-P detected in | mouse brain tissue |
| Recommended Dilutions — Western Blot (WB) | WB : 1:500-1:1000 |
| Recommended Dilutions — Immunoprecipitation (IP) | IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate |
| Recommended Dilutions — Immunofluorescence (IF)-P | IF-P : 1:50-1:500 |
| Positive WB detected in | mouse brain tissue |
| Positive IP detected in | rat brain tissue |
| Positive IF-P detected in | mouse brain tissue |
| Western Blot (WB) | WB : 1:500-1:1000 |
| Immunoprecipitation (IP) | IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate |
| Immunofluorescence (IF)-P | IF-P : 1:50-1:500 |
| Tested Reactivity | human, mouse, rat |
| Cited Reactivity | human |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | CatNo: Ag3275 Product name: Recombinant human SERPINI1 protein Source: e coli. -derived, PGEX-4T Tag: GST Domain: 109-410 aa of BC018043 Sequence: ANSLFVQNGFHVNEEFLQMMKKYFNAAVNHVDFSQNVAVANYINKWVENNTNNLVKDLVSPRDFDAATYLALINAVYFKGNWKSQFRPENTRTFSFTKDDESEVQIPMMYQQGEFYYGEFSDGSNEAGGIYQVLEIPYEGDEISMMLVLSRQEVPLATLEPLVKAQLVEEWANSVKKQKVEVYLPRFTVEQEIDLKDVLKALGITEIFIKDANLTGLYDNKEIFLSKAIHKSFLEVNEEGSEAAAVSGMIAISRMAVLYPQVIVDHPFFFLIRNRRTGTILFMGRVMHPETMNTSGHDFEEL Predict reactive species |
| Full Name | serpin peptidase inhibitor, clade I (neuroserpin), member 1 |
| Calculated Molecular Weight | 410 aa, 47 kDa |
| Observed Molecular Weight | 46 kDa |
| GenBank Accession Number | BC018043 |
| Gene Symbol | Neuroserpin |
| Gene ID (NCBI) | 5274 |
| RRID | AB_10642703 |
| Conjugate | Unconjugated |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | Q99574 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA. |
| IF protocol for Neuroserpin antibody 12558-1-AP | Download protocol |
| IP protocol for Neuroserpin antibody 12558-1-AP | Download protocol |
| WB protocol for Neuroserpin antibody 12558-1-AP | Download protocol |
| human | IP Sci Rep SERPINI1 functions as a tumor suppressor in glioma. Authors - Shuang Luo View Article |
| Citations | 1 |
| Dilutions | WB : 1:500-1:1000 IP : 0.5-4.0 ug for IP and 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate for WB IF-P : 1:50-1:500 |
| Isotype | IgG |
| Clonality | Polyclonal |
| Clone Number | - |
| Conjugation | Unconjugated |
Neuroserpin is a member of the serpin family of serine protease inhibitors predominantly expressed in the nervous system, such as s the cerebral cortex, hippocampus and the spinal cord.Neuroserpin exerts protective effects in neurons against excitotoxicity both in vitro and in vivo. Its proteolytic inhibitory activity is shown to protect neurons against damage caused by plasmin activation. Mice overexpressing neuroserpin exhibited loss of tPA activity in the brain. Overexpression of neuroserpin in primary neurons leads to increased dendritic arborization and altered dendritic spine shape. Protocols Product Specific Protocols IF protocol for Neuroserpin antibody 12558-1-AP Download protocol IP protocol for Neuroserpin antibody 12558-1-AP Download protocol WB protocol for Neuroserpin antibody 12558-1-AP Download protocol Standard Protocols Click here to view our Standard Protocols
Publications
- SERPINI1 functions as a tumor suppressor in glioma.
Journal: Sci Rep | Authors: Shuang Luo | Species: human | Application: IP
Reviews
Write Your Own Review
Related Products
Check items to add to the cart or
