SHC4 Recombinant monoclonal antibody 85181-4-RR proteintech
$149.00
In stock
SKU
85181-4-RR
| Catalog Number | 85181-4-RR |
| Synonyms | 242805E3, hShcD, Rai like protein, Rai-like protein, RaLP |
| Host | Rabbit |
| Reactivity | human |
| Form | Liquid |
| Formulation | PBS, Azide, Glycerol |
| Applications | WB, IF/ICC, ELISA |
| Host / Isotype | Rabbit / IgG |
| Tested Applications — Positive WB detected in | fetal human brain tissue, A375 cells, HepG2 Cells |
| Tested Applications — Positive IF/ICC detected in | HepG2 cells, SH-SY5Y cells |
| Recommended Dilutions — Western Blot (WB) | WB : 1:5000-1:50000 |
| Recommended Dilutions — Immunofluorescence (IF)/ICC | IF/ICC : 1:50-1:500 |
| Positive WB detected in | fetal human brain tissue, A375 cells, HepG2 Cells |
| Positive IF/ICC detected in | HepG2 cells, SH-SY5Y cells |
| Western Blot (WB) | WB : 1:5000-1:50000 |
| Immunofluorescence (IF)/ICC | IF/ICC : 1:50-1:500 |
| Tested Reactivity | human |
| Class | Recombinant |
| Type | Antibody |
| Immunogen | CatNo: Ag3336 Product name: Recombinant human SHC4 protein Source: e coli. -derived, PGEX-4T Tag: GST Domain: 324-630 aa of BC033907 Sequence: NGMAQDVISTIGQAFELRFKQYLKNPSLNTSCESEEVHIDSHAEEREDHEYYNEIPGKQPPVGGVSDMRIKVQATEQMAYCPIQCEKLCYLPGNSKCSSVYENCLEQSRAIGNVHPRGVQSQRGTSLLKHTCRVDLFDDPCYINTQALQSTPGSAGNQRSAQPLGSPWHCGKAPETVQPGATAQPASSHSLPHIKQQLWSEECYHGKLSRKAAESLLVKDGDFLVRESATSPGQYVLSGLQGGQAKHLLLVDPEGKVRTKDHVFDNVGHLIRYHMDNSLPIISSGSEVSLKQPVRKDNNPALLHSNK Predict reactive species |
| Full Name | SHC (Src homology 2 domain containing) family, member 4 |
| Calculated Molecular Weight | 630 aa, 69 kDa |
| Observed Molecular Weight | 75 kDa |
| GenBank Accession Number | BC033907 |
| Gene Symbol | SHC4 |
| Gene ID (NCBI) | 399694 |
| RRID | AB_3744080 |
| Conjugate | Unconjugated |
| Purification Method | Protein A purification |
| UNIPROT ID | Q6S5L8 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA. |
| IF protocol for SHC4 antibody 85181-4-RR | Download protocol |
| WB protocol for SHC4 antibody 85181-4-RR | Download protocol |
| Citations | - |
| Dilutions | WB : 1:5000-1:50000 IF/ICC : 1:50-1:500 |
| Isotype | IgG |
| Clonality | Recombinant |
| Clone Number | 242805E3 |
| Conjugation | Unconjugated |
SHC4 is a member of the SHC family and is characterized by a phosphotyrosine binding (PTB) domain and Src homology 2 (SH2) domain, which both bind to phosphorylated tyrosine residues on cell surface receptors and other signaling proteins. SHC family proteins contain the proline- and glycine-rich domains termed collagen homology 1 (CH1) and CH2 domains, which act as docking sites for certain proteins. Abnormal SHC4 expression promotes cell migration and invasion in melanoma, glioma, and hepatocellular carcinoma (PMID: 38052369). Protocols Product Specific Protocols IF protocol for SHC4 antibody 85181-4-RR Download protocol WB protocol for SHC4 antibody 85181-4-RR Download protocol Standard Protocols Click here to view our Standard Protocols
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