SNX12 Monoclonal antibody, PBS Only 68260-1-PBS proteintech
$699.00
In stock
SKU
68260-1-PBS
| Catalog Number | 68260-1-PBS |
| Synonyms | Sorting nexin-12, 2C6C8 |
| Host | Mouse |
| Reactivity | human, mouse, rat |
| Form | Liquid |
| Formulation | PBS Only |
| Applications | WB, IF/ICC, Indirect ELISA |
| Host / Isotype | Mouse / IgG2b |
| Tested Reactivity | human, mouse, rat |
| Class | Monoclonal |
| Type | Antibody |
| Immunogen | CatNo: Ag3014 Product name: Recombinant human SNX12 protein Source: e coli. -derived, T-HIS Tag: 6*His Domain: 1-162 aa of BC020559 Sequence: MSDTAVADTRRLNSKPQDLTDAYGPPSNFLEIDIFNPQTVGVGRARFTTYEVRMRTNLPIFKLKESCVRRRYSDFEWLKNELERDSKIVVPPLPGKALKRQLPFRGDEGIFEESFIEERRQGLEQFINKIAGHPLAQNERCLHMFLQEEAIDRNYVPGKSLA Predict reactive species |
| Full Name | sorting nexin 12 |
| Calculated Molecular Weight | 172 aa, 20 kDa |
| Observed Molecular Weight | 18 kDa |
| GenBank Accession Number | BC020559 |
| Gene Symbol | SNX12 |
| Gene ID (NCBI) | 29934 |
| RRID | AB_2935345 |
| Conjugate | Unconjugated |
| Purification Method | Protein A purification |
| UNIPROT ID | Q9UMY4 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
| Citations | - |
| Isotype | IgG2b |
| Clonality | Monoclonal |
| Clone Number | 2C6C8 |
| Conjugation | Unconjugated |
SNXs (sorting nexins) are a diverse group of cytoplasmic and membrane-associated proteins that are classified by the presence of a phospholipid-binding motif-the PX domain (PMID:12461558). SNXs are involved in endocytosis and protein trafficking. SNX12 (Sorting nexin 12) is localized in early endosomes and SNX12 overexpression specifically prevents the degradative pathway from early to late endosomes/lysosomes (PMID: 22719997). SNX12 may participate in Alzheimer's disease (AD) pathology by regulating the endocytosis of BACE1 and affecting β-processing of APP (PMID: 22709416).
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