SORLA Monoclonal antibody 68651-1-Ig proteintech
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SKU
68651-1-Ig
| Catalog Number | 68651-1-Ig |
| Synonyms | SORL1, SORL 1, Low-density lipoprotein receptor relative with 11 ligand-binding repeats, LDLR relative with 11 ligand-binding repeats, C11orf32 |
| Host | Mouse |
| Reactivity | human |
| Form | Liquid |
| Formulation | PBS, Azide, Glycerol |
| Applications | WB, IF-P, ELISA |
| Host / Isotype | Mouse / IgG1 |
| Tested Applications — Positive WB detected in | LNCaP cells |
| Tested Applications — Positive IF-P detected in | mouse cerebellum tissue |
| Recommended Dilutions — Western Blot (WB) | WB : 1:1000-1:4000 |
| Recommended Dilutions — Immunofluorescence (IF)-P | IF-P : 1:200-1:800 |
| Positive WB detected in | LNCaP cells |
| Positive IF-P detected in | mouse cerebellum tissue |
| Western Blot (WB) | WB : 1:1000-1:4000 |
| Immunofluorescence (IF)-P | IF-P : 1:200-1:800 |
| Tested Reactivity | human |
| Class | Monoclonal |
| Type | Antibody |
| Immunogen | CatNo: Ag18445 Product name: Recombinant human SORL1 protein Source: e coli. -derived, PET28a Tag: 6*His Domain: 1865-2214 aa of BC137171 Sequence: PRNVVYGIFYATSFLDLYRNPKSLTTSLHNKTVIVSKDEQYLFLVRVVVPYQGPSSDYVVVKMIPDSRLPPRHLHVVHTGKTSVVIKWESPYDSPDQDLLYAIAVKDLIRKTDRSYKVKSRNSTVEYTLNKLEPGGKYHIIVQLGNMSKDSSIKITTVSLSAPDALKIITENDHVLLFWKSLALKEKHFNESRGYEIHMFDSAMNITAYLGNTTDNFFKISNLKMGHNYTFTVQARCLFGNQICGEPAILLYDELGSGADASATQAARSTDVAAVVVPILFLILLSLGVGFAILYTKHRRLQSSFTAFANSHYSSRLGSAIFSSGDDLGEDDEDAPMITGFSDDVPMVIA Predict reactive species |
| Full Name | sortilin-related receptor, L(DLR class) A repeats-containing |
| Calculated Molecular Weight | 2214 aa, 248 kDa |
| Observed Molecular Weight | 300 kDa |
| GenBank Accession Number | BC137171 |
| Gene Symbol | SORLA |
| Gene ID (NCBI) | 6653 |
| RRID | AB_3670393 |
| Conjugate | Unconjugated |
| Purification Method | Protein G purification |
| UNIPROT ID | Q92673 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA. |
| IF protocol for SORLA antibody 68651-1-Ig | Download protocol |
| WB protocol for SORLA antibody 68651-1-Ig | Download protocol |
| Citations | - |
| Dilutions | WB : 1:1000-1:4000 IF-P : 1:200-1:800 |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Clone Number | 2E7D9 |
| Conjugation | Unconjugated |
SorLA also known as SorL1 or LR11, is a multiligand receptor belonging to the LDL receptor superfamily. It is also a member of vacuolar protein sorting-10 (Vps10) family and is enriched in the brain. SorLA acts as an sorting receptor for APP and prevents amyloidogenic processing of APP. Downregulation of SorLA has been found in patients with sporadic Alzheimer disease (AD). Currently SorLA has emerged as a potential target for AD therapy. (25404298) Protocols Product Specific Protocols IF protocol for SORLA antibody 68651-1-Ig Download protocol WB protocol for SORLA antibody 68651-1-Ig Download protocol Standard Protocols Click here to view our Standard Protocols
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