STK11/LKB1 Polyclonal antibody 29323-1-AP proteintech
$149.00
In stock
SKU
29323-1-AP
| Catalog Number | 29323-1-AP |
| Synonyms | LKB1, PJS, serine/threonine kinase 11, STK11 |
| Host | Rabbit |
| Reactivity | Human, Mouse and More (1) |
| Reactivity | human, mouse |
| Form | Liquid |
| Formulation | PBS, Azide, Glycerol |
| Applications | WB, IHC, ELISA |
| Host / Isotype | Rabbit / IgG |
| Tested Applications — Positive WB detected in | A431 cells, MCF-7 cells, HEK-293T cells |
| Tested Applications — Positive IHC detected in | human lung cancer tissue, human breast cancer tissue, mouse testis tissue, human lymphoma tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Recommended Dilutions — Western Blot (WB) | WB : 1:2000-1:10000 |
| Recommended Dilutions — Immunohistochemistry (IHC) | IHC : 1:300-1:1200 |
| Positive WB detected in | A431 cells, MCF-7 cells, HEK-293T cells |
| Positive IHC detected in | human lung cancer tissue, human breast cancer tissue, mouse testis tissue, human lymphoma tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Western Blot (WB) | WB : 1:2000-1:10000 |
| Immunohistochemistry (IHC) | IHC : 1:300-1:1200 |
| Tested Reactivity | Human, Mouse |
| Cited Reactivity | mouse |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | CatNo: Ag30903 Product name: Recombinant human STK11 protein Source: e coli. -derived, PGEX-4T Tag: GST Domain: 281-428 aa of BC007981 Sequence: PLSDLLKGMLEYEPAKRFSIRQIRQHSWFRKKHPPAEAPVPIPPSPDTKDRWRSMTVVPYLEDLHGADEDEDLFDIEDDIIYTQDFTVPGQVPEEEASHNGQRRGLPKAVCMNGTEAAQLSTKSRAEGRAPNPARKACSASSKIRRLS Predict reactive species |
| Full Name | serine/threonine kinase 11 |
| Calculated Molecular Weight | 49 kDa |
| Observed Molecular Weight | 50-55 kDa |
| GenBank Accession Number | BC007981 |
| Gene Symbol | LKB1 |
| Gene ID (NCBI) | 6794 |
| RRID | AB_2923591 |
| Conjugate | Unconjugated |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | Q15831 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA. |
| IHC protocol for STK11/LKB1 antibody 29323-1-AP | Download protocol |
| WB protocol for STK11/LKB1 antibody 29323-1-AP | Download protocol |
| mouse | WB Free Radic Res Apelin deficiency exacerbates cardiac injury following infarction by accelerating cardiomyocyte ferroptosis Authors - Yuechu Zhao View Article |
| Citations | 2 |
| Dilutions | WB : 1:2000-1:10000 IHC : 1:300-1:1200 |
| Isotype | IgG |
| Clonality | Polyclonal |
| Clone Number | - |
| Conjugation | Unconjugated |
STK11(serine/threonine-protein kinase 11) is also named as LKB1, PJS, and belongs to the protein kinase superfamily. It controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. The tumour suppressor protein LKB1 is a serine/threonine kinase that has been causally linked to Peutz-Jeghers syndrome (PJS). Defects in STK11 are a cause of Peutz-Jeghers syndrome (PJS) and defects in STK11 have been associated with testicular germ cell tumor (TGCT) and some sporadic cancers, especially lung cancers. STK11 has 2 isoforms with MW of 49 kDa and 45 kDa, and can be detected as 50-54 kDa after posttranslational modification. Protocols Product Specific Protocols IHC protocol for STK11/LKB1 antibody 29323-1-AP Download protocol WB protocol for STK11/LKB1 antibody 29323-1-AP Download protocol Standard Protocols Click here to view our Standard Protocols
Publications
- Apelin deficiency exacerbates cardiac injury following infarction by accelerating cardiomyocyte ferroptosis
Journal: Free Radic Res | Authors: Yuechu Zhao | Species: mouse | Application: WB - STK11 c.1062 C > G germline variant in medullary thyroid carcinoma: implications for familial predisposition and genetic counseling.
Journal: Endocrine | Authors: Weimao Kong
Reviews
Write Your Own Review
Related Products
Check items to add to the cart or
