CoraLite® Plus 647 Anti-Human TIM3 Rabbit Recombinant Antibody CL647-98115 proteintech
$217.00
In stock
SKU
CL647-98115
| Catalog Number | CL647-98115 |
| Synonyms | 241422H1, CD366, HAVCR2, HAVcr-2, T-cell immunoglobulin and mucin domain-containing protein 3 |
| Host | Rabbit |
| Reactivity | human |
| Form | Liquid |
| Formulation | PBS, Azide, BSA |
| Applications | FC |
| Host / Isotype | Rabbit / IgG |
| Tested Applications — Positive FC detected in | Anti-CD3/CD28 treated human PBMCs |
| Positive FC detected in | Anti-CD3/CD28 treated human PBMCs |
| Flow Cytometry (FC) | FC : 5 ul per 10^6 cells in a 100 µl suspension |
| Tested Reactivity | human |
| Class | Recombinant |
| Type | Antibody |
| Immunogen | Recombinant Protein Predict reactive species |
| Full Name | hepatitis A virus cellular receptor 2 |
| Calculated Molecular Weight | 301 aa, 33 kDa |
| GenBank Accession Number | BC020843 |
| Gene Symbol | TIM3 |
| Gene ID (NCBI) | 84868 |
| RRID | AB_3748739 |
| Conjugate | CoraLite® Plus 647 Fluorescent Dye |
| Excitation/Emission Maxima Wavelengths | 654 nm / 674 nm |
| Excitation Laser | Red Laser (633 nm) |
| Purification Method | Protein A purification |
| UNIPROT ID | Q8TDQ0 |
| Storage Buffer | PBS with 0.09% sodium azide and 0.5% BSA, pH 7.3. |
| Storage Conditions | Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment. |
| FC protocol for CL Plus 647 TIM3 antibody CL647-98115 | Download protocol |
| Citations | 1 |
| Isotype | IgG |
| Clonality | Recombinant |
| Clone Number | 241422H1 |
| Conjugation | CoraLite® Plus 647 |
TIM3, also known as HAVCR2, is a member of the recently discovered T cell Ig and mucin domain-containing molecule superfamily. TIM3 is a negative regulatory molecule that is important for T cell tolerance and has a crucial role in autoimmunity and T cell exhaustion during chronic viral infection (PMID: 23180819). TIM3 is expressed by T-helper type 1 (Th1) cells, macrophage, monocyte, dendritic cells, CD8+ T cell and other lymphocyte subsets. Galectin-9 is a ligand for TIM3. TIM3-galectin-9 pathway negatively regulates T helper type 1 immunity (PMID: 16286920). Protocols Product Specific Protocols FC protocol for CL Plus 647 TIM3 antibody CL647-98115 Download protocol Standard Protocols Click here to view our Standard Protocols
Publications
- ARTN drives CD8(+) T cell exhaustion via the GFRα3-RET-PI3K/AKT Axis to promote TNBC progression.
Journal: Cell Signal | Authors: Dongke Yan
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