TNF-alpha Recombinant monoclonal antibody 83721-7-RR proteintech
$149.00
In stock
SKU
83721-7-RR
| Catalog Number | 83721-7-RR |
| Synonyms | TNF, TNF alpha, TNF-a, 240668B4, C-domain 1 |
| Host | Rabbit |
| Reactivity | human and More (1) |
| Reactivity | human, rat |
| Form | Liquid |
| Formulation | PBS, Azide, Glycerol |
| Applications | WB, ELISA |
| Host / Isotype | Rabbit / IgG |
| Tested Applications — Positive WB detected in | THP-1 cells, LPS treated THP-1 cells |
| Recommended Dilutions — Western Blot (WB) | WB : 1:2000-1:10000 |
| Positive WB detected in | THP-1 cells, LPS treated THP-1 cells |
| Western Blot (WB) | WB : 1:2000-1:10000 |
| Tested Reactivity | human |
| Cited Reactivity | rat |
| Class | Recombinant |
| Type | Antibody |
| Immunogen | Recombinant protein Predict reactive species |
| Full Name | tumor necrosis factor (TNF superfamily, member 2) |
| Calculated Molecular Weight | 26 kDa |
| Observed Molecular Weight | 26 kDa |
| GenBank Accession Number | NM_000594.4 |
| Gene Symbol | TNF-alpha |
| Gene ID (NCBI) | 7124 |
| ENSEMBL Gene ID | ENSG00000232810 |
| RRID | AB_3671322 |
| Conjugate | Unconjugated |
| Purification Method | Protein A purfication |
| UNIPROT ID | P01375 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA. |
| WB protocol for TNF-alpha antibody 83721-7-RR | Download protocol |
| rat | WB J Inflamm Res Astragaloside IV Attenuates Chronic Prostatitis by Activating Keap1/Nrf2/HO-1 Pathway: Suppressing Ferroptosis and Enhancing Antioxidant Defense Authors - Jintao Shi View Article |
| Citations | 1 |
| Dilutions | WB : 1:2000-1:10000 |
| Isotype | IgG |
| Clonality | Recombinant |
| Clone Number | 240668B4 |
| Conjugation | Unconjugated |
TNF, as also known as TNF-alpha, or cachectin, is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. It is expressed as a 26 kDa membrane bound protein and is then cleaved by TNF-alpha converting enzyme (TACE) to release the soluble 17 kDa monomer, which forms homotrimers in circulation. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, ins resistance, and cancer. Protocols Product Specific Protocols WB protocol for TNF-alpha antibody 83721-7-RR Download protocol Standard Protocols Click here to view our Standard Protocols
Publications
- Astragaloside IV Attenuates Chronic Prostatitis by Activating Keap1/Nrf2/HO-1 Pathway: Suppressing Ferroptosis and Enhancing Antioxidant Defense
Journal: J Inflamm Res | Authors: Jintao Shi | Species: rat | Application: WB
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