CoraLite®594-conjugated TOM70 Polyclonal antibody CL594-14528 proteintech
$479.00
In stock
SKU
CL594-14528
| Catalog Number | CL594-14528 |
| Synonyms | TOMM70A, KIAA0719, TOMM, TOMM70, Translocase of outer mitochondrial membrane protein 70 |
| Host | Rabbit |
| Reactivity | human, mouse, rat and More (1) |
| Reactivity | human, mouse, rat, zebrafish |
| Form | Liquid |
| Formulation | PBS, Proclin300, BSA, Glycerol |
| Applications | IF/ICC, FC (Intra) |
| Host / Isotype | Rabbit / IgG |
| Tested Applications — Positive IF/ICC detected in | HepG2 cells |
| Tested Applications — Positive FC (Intra) detected in | HepG2 cells |
| Recommended Dilutions — Immunofluorescence (IF)/ICC | IF/ICC : 1:50-1:500 |
| Recommended Dilutions — Flow Cytometry (FC) (INTRA) | FC (INTRA) : 0.40 ug per 10^6 cells in a 100 µl suspension |
| Positive IF/ICC detected in | HepG2 cells |
| Positive FC (Intra) detected in | HepG2 cells |
| Immunofluorescence (IF)/ICC | IF/ICC : 1:50-1:500 |
| Flow Cytometry (FC) (INTRA) | FC (INTRA) : 0.40 ug per 10^6 cells in a 100 µl suspension |
| Tested Reactivity | human, mouse, rat |
| Cited Reactivity | human, zebrafish |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | CatNo: Ag6027 Product name: Recombinant human TOM70 protein Source: e coli. -derived, PGEX-4T Tag: GST Domain: 245-608 aa of BC052994 Sequence: KNREPLMPSPQFIKSYFSSFTDDIISQPMLKGEKSDEDKDKEGEALEVKENSGYLKAKQYMEEENYDKIISECSKEIDAEGKYMAEALLLRATFYLLIGNANAAKPDLDKVISLKEANVKLRANALIKRGSMYMQQQQPLLSTQDFNMAADIDPQNADVYHHRGQLKILLDQVEEAVADFDECIRLRPESALAQAQKCFALYRQAYTGNNSSQIQAAMKGFEEVIKKFPRCAEGYALYAQALTDQQQFGKADEMYDKCIDLEPDNATTYVHKGLLQLQWKQDLDRGLELISKAIEIDNKCDFAYETMGTIEVQRGNMEKAIDMFNKAINLAKSEMEMAHLYSLCDAAHAQTEVAKKYGLKPPTL Predict reactive species |
| Full Name | translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae) |
| Calculated Molecular Weight | 67 kDa |
| GenBank Accession Number | BC052994 |
| Gene Symbol | TOM70 |
| Gene ID (NCBI) | 9868 |
| RRID | AB_2919809 |
| Conjugate | CoraLite®594 Fluorescent Dye |
| Excitation/Emission Maxima Wavelengths | 588 nm / 604 nm |
| Excitation Laser | Yellow-Green Laser (561 nm) |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | O94826 |
| Storage Buffer | PBS with 50% glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3. |
| Storage Conditions | Store at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. |
| FC protocol for CL594 TOM70 antibody CL594-14528 | Download protocol |
| IF protocol for CL594 TOM70 antibody CL594-14528 | Download protocol |
| zebrafish | IF Dis Model Mech Patient-specific mutation of a contact site protein Tomm70 causes neurodegeneration in a zebrafish model Authors - Vranda Garg View Article |
| human | IF PLoS Pathog Mitochondrial targeting by measles virus nucleoprotein modulates viral spread in human airway epithelium. Authors - Lorellin A. Durnell-Bettis View Article |
| Citations | 2 |
| Dilutions | IF/ICC : 1:50-1:500 FC (INTRA) : 0.40 ug per 10^6 cells in a 100 µl suspension |
| Isotype | IgG |
| Clonality | Polyclonal |
| Clone Number | - |
| Conjugation | CoraLite®594 |
TOMM70A (or TOM70) is a mitochondrial import receptor responsible for the import of cytosol synthesized precursor proteins into the mitochondria. Tom70 is a member of the tetratricopeptide repeat (TPR) co-chaperone family and contains a conserved TPR clamp domain for interaction with Hsc70 and Hsp90. Recently overexpression of TOM70 has been linked to chemoresistance to drugs in breast cancer cell lines. It is also believed that Tom70 is significantly associated with breast cancer relapse and may predict the recurrence of ovarian cancer. Protocols Product Specific Protocols FC protocol for CL594 TOM70 antibody CL594-14528 Download protocol IF protocol for CL594 TOM70 antibody CL594-14528 Download protocol Standard Protocols Click here to view our Standard Protocols
Publications
- Patient-specific mutation of a contact site protein Tomm70 causes neurodegeneration in a zebrafish model
Journal: Dis Model Mech | Authors: Vranda Garg | Species: zebrafish | Application: IF - Mitochondrial targeting by measles virus nucleoprotein modulates viral spread in human airway epithelium.
Journal: PLoS Pathog | Authors: Lorellin A. Durnell-Bettis | Species: human | Application: IF
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