TROVE2 Polyclonal antibody 12718-1-AP proteintech
$149.00
In stock
SKU
12718-1-AP
| Catalog Number | 12718-1-AP |
| Synonyms | SS A, RoRNP, Ro60 autoantigen, RO60, RNA-binding protein RO60 |
| Host | Rabbit |
| Reactivity | human, mouse, rat |
| Form | Liquid |
| Formulation | PBS, Azide, Glycerol |
| Applications | WB, IF/ICC, ELISA |
| Host / Isotype | Rabbit / IgG |
| Tested Applications — Positive WB detected in | MCF7 cells, HeLa cells, mouse thymus tissue, PC-3 cells, rat spleen tissue |
| Tested Applications — Positive IF/ICC detected in | PC-3 cells |
| Recommended Dilutions — Western Blot (WB) | WB : 1:500-1:3000 |
| Recommended Dilutions — Immunofluorescence (IF)/ICC | IF/ICC : 1:200-1:800 |
| Positive WB detected in | MCF7 cells, HeLa cells, mouse thymus tissue, PC-3 cells, rat spleen tissue |
| Positive IF/ICC detected in | PC-3 cells |
| Western Blot (WB) | WB : 1:500-1:3000 |
| Immunofluorescence (IF)/ICC | IF/ICC : 1:200-1:800 |
| Tested Reactivity | human, mouse, rat |
| Cited Reactivity | human |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | CatNo: Ag3412 Product name: Recombinant human TROVE2 protein Source: e coli. -derived, PGEX-4T Tag: GST Domain: 21-369 aa of BC036658 Sequence: DGYVWQVTDMNRLHRFLCFGSEGGTYYIKEQKLGLENAEALIRLIEDGRGCEVIQEIKSFSQEGRTTKQEPMLFALAICSQCSDISTKQAAFKAVSEVCRIPTHLFTFIQFKKDLKESMKCGMWGRALRKAIADWYNEKGGMALALAVTKYKQRNGWSHKDLLRLSHLKPSSEGLAIVTKYITKGWKEVHELYKEKALSVETEKLLKYLEAVEKVKRTRDELEVIHLIEEHRLVREHLLTNHLKSKEVWKALLQEMPLTALLRNLGKMTANSVLEPGNSEVSLVCEKLCNEKLLKKARIHPFHILIALETYKTGHGLRGKLKWRPDEEILKALDAAFYKTFKTVEPTGK Predict reactive species |
| Full Name | TROVE domain family, member 2 |
| Calculated Molecular Weight | 60 kDa |
| Observed Molecular Weight | 60 kDa |
| GenBank Accession Number | BC036658 |
| Gene Symbol | TROVE2 |
| Gene ID (NCBI) | 6738 |
| RRID | AB_2209756 |
| Conjugate | Unconjugated |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | P10155 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA. |
| IF protocol for TROVE2 antibody 12718-1-AP | Download protocol |
| WB protocol for TROVE2 antibody 12718-1-AP | Download protocol |
| human | WB J Exp Clin Cancer Res Selective sorting and secretion of hY4 RNA fragments into extracellular vesicles mediated by methylated YBX1 to promote lung cancer progression. Authors - Chuang Li View Article |
| Citations | 1 |
| Dilutions | WB : 1:500-1:3000 IF/ICC : 1:200-1:800 |
| Isotype | IgG |
| Clonality | Polyclonal |
| Clone Number | - |
| Conjugation | Unconjugated |
TROVE2, also named as RO60 or RoRNP, is a 538 amino acid protein, which is localized in cytoplasmic mRNP granules containing untranslated mRNAs. TROVE2 as a RNA-binding protein that binds to misfolded non-coding RNAs, pre-5S rRNA, and several small cytoplasmic RNA molecules known as Y RNAs. TROVE2 may stabilize some of these RNAs and protect them from degradation (PubMed:18056422). TROVE2 binds to endogenous Alu retroelements which are induced by type I IFN and stimulate porinflammaotry cytokine secretion. Protocols Product Specific Protocols IF protocol for TROVE2 antibody 12718-1-AP Download protocol WB protocol for TROVE2 antibody 12718-1-AP Download protocol Standard Protocols Click here to view our Standard Protocols
Publications
- Selective sorting and secretion of hY4 RNA fragments into extracellular vesicles mediated by methylated YBX1 to promote lung cancer progression.
Journal: J Exp Clin Cancer Res | Authors: Chuang Li | Species: human | Application: WB
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