Tyrosinase Recombinant monoclonal antibody 84723-3-RR proteintech
$149.00
In stock
SKU
84723-3-RR
| Catalog Number | 84723-3-RR |
| Synonyms | TYR, 242174D2, EC:1.14.18.1, LB24 AB, LB24-AB |
| Host | Rabbit |
| Reactivity | human |
| Form | Liquid |
| Formulation | PBS, Azide, Glycerol |
| Applications | WB, ELISA |
| Host / Isotype | Rabbit / IgG |
| Tested Applications — Positive WB detected in | A549 cells, A375 cells, L02 cells |
| Recommended Dilutions — Western Blot (WB) | WB : 1:1000-1:4000 |
| Positive WB detected in | A549 cells, A375 cells, L02 cells |
| Western Blot (WB) | WB : 1:1000-1:4000 |
| Tested Reactivity | human |
| Class | Recombinant |
| Type | Antibody |
| Immunogen | CatNo: Ag34940 Product name: Recombinant human Tyrosinase protein Source: e coli. -derived, PGEX-4T Tag: GST Domain: 19-200 aa of BC027179 Sequence: HFPRACVSSKNLMEKECCPPWSGDRSPCGQLSGRGSCQNILLSNAPLGPQFPFTGVDDRESWPSVFYNRTCQCSGNFMGFNCGNCKFGFWGPNCTERRLLVRRNIFDLSAPEKDKFFAYLTLAKHTISSDYVIPIGTYGQMKNGSTPMFNDINIYDLFVWMHYYVSMDALLGGSEIWRDIDF Predict reactive species |
| Full Name | tyrosinase (oculocutaneous albinism IA) |
| Calculated Molecular Weight | 529 aa, 60 kDa |
| Observed Molecular Weight | 80 kDa |
| GenBank Accession Number | BC027179 |
| Gene Symbol | TYR |
| Gene ID (NCBI) | 7299 |
| RRID | AB_3743683 |
| Conjugate | Unconjugated |
| Purification Method | Protein A purfication |
| UNIPROT ID | P14679 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA. |
| WB protocol for Tyrosinase antibody 84723-3-RR | Download protocol |
| Citations | - |
| Dilutions | WB : 1:1000-1:4000 |
| Isotype | IgG |
| Clonality | Recombinant |
| Clone Number | 242174D2 |
| Conjugation | Unconjugated |
Tyrosinase is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. It's a melanocyte-specific enzyme critical for the synthesis of melanin, a process normally restricted to a post-Golgi compartment termed the melanosome. Loss-of-function mutations in tyrosinase are the cause of oculocutaneous albinism. The 60-kDa tyrosinase core polypeptide is modified in the endoplasmic reticulum (ER) by cotranslational addition of multiple N-linked glycans, producing the 70-kDa species. Complex sugar modifications in the Golgi apparatus further increases tyrosinase's molecular mass to 80 kDa, the size of the mature wild-type (WT) isoform. (PMID:10823941) Protocols Product Specific Protocols WB protocol for Tyrosinase antibody 84723-3-RR Download protocol Standard Protocols Click here to view our Standard Protocols
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