ZNF410 Polyclonal antibody 14529-1-AP proteintech
$149.00
In stock
SKU
14529-1-AP
| Catalog Number | 14529-1-AP |
| Synonyms | Zinc finger protein APA 1, Zinc finger protein 410, APA1, APA 1, Another partner for ARF 1 |
| Host | Rabbit |
| Reactivity | human, mouse, rat |
| Form | Liquid |
| Formulation | PBS, Azide, Glycerol |
| Applications | WB, IF, ChIP, ELISA |
| Applications | WB, ELISA |
| Host / Isotype | Rabbit / IgG |
| Tested Applications — Positive WB detected in | HEK-293 cells, MCF-7 cells, mouse brain tissue, HeLa cells, U2OS cells |
| Recommended Dilutions — Western Blot (WB) | WB : 1:500-1:3000 |
| Positive WB detected in | HEK-293 cells, MCF-7 cells, mouse brain tissue, HeLa cells, U2OS cells |
| Western Blot (WB) | WB : 1:500-1:3000 |
| Tested Reactivity | human, mouse, rat |
| Cited Reactivity | human, mouse |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | CatNo: Ag6028 Product name: Recombinant human ZNF410 protein Source: e coli. -derived, PGEX-4T Tag: GST Domain: 1-351 aa of BC050683 Sequence: MLSDELESKPELLVQFVQNTSIPLGQGLVESEAKDITCLSLLPVTEASECSRLMLPDDTTNHSNSSKEVPSSAVLRSLRVNVGPDGEETRAQTVQKSPEFLSTSESSSLLQDLQPSDSTSFILLNLTRAGLGSSAEHLVFVQDEAEDSGNDFLSSESTDSSIPWFLRVQELAHDSLIAATRAQLAKNAKTSSNGENVHLGSGDGQSKDSGPLPQVEKKLKCTVEGCDRTFVWPAHFKYHLKTHRNDRSFICPAEGCGKSFYVLQRLKVHMRTHNGEKPFMCHESGCGKQFTTAGNLKNHRRIHTGEKPFLCEAQGCGRSFAEYSSLRKHLVVHSGEKPHQCQVCGKTFSQS Predict reactive species |
| Full Name | zinc finger protein 410 |
| Calculated Molecular Weight | 52 kDa |
| Observed Molecular Weight | 52-67 kDa |
| GenBank Accession Number | BC050683 |
| Gene Symbol | ZNF410 |
| Gene ID (NCBI) | 57862 |
| RRID | AB_2257520 |
| Conjugate | Unconjugated |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | Q86VK4 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA. |
| WB protocol for ZNF410 antibody 14529-1-AP | Download protocol |
| human | WB,ChIP Cell Rep SWI/SNF complex-mediated ZNF410 cooperative binding maintains chromatin accessibility and enhancer activity Authors - Siyuan Xu View Article |
| mouse | WB EMBO J PGE2 -EP3 axis promotes brown adipose tissue formation through stabilization of WTAP RNA methyltransferase. Authors - Xixi Tao View Article |
| Citations | 9 |
| Dilutions | WB : 1:500-1:3000 |
| Isotype | IgG |
| Clonality | Polyclonal |
| Clone Number | - |
| Conjugation | Unconjugated |
ZNF410 (Zinc Finger Protein 410) is a transcription factor involved in the regulation of gene expression, particularly in the context of fetal hemoglobin (HbF) repression and chromatin remodeling. This protein is highly conserved among mammals and plays a crucial role in erythroid cells. The study found that ZNF410 uniquely silences HbF by activating its sole target gene, CHD4, a known HbF repressor in erythroid cells. (PMID: 40158221) Protocols Product Specific Protocols WB protocol for ZNF410 antibody 14529-1-AP Download protocol Standard Protocols Click here to view our Standard Protocols
Publications
- ZNF410 represses fetal globin by singular control of CHD4.
Journal: Nat Genet | Authors: Divya S Vinjamur KO Validated | Species: human | Application: WB - ZNF410 Uniquely Activates the NuRD Component CHD4 to Silence Fetal Hemoglobin Expression.
Journal: Mol Cell | Authors: Xianjiang Lan | Species: human | Application: WB - PGE2 -EP3 axis promotes brown adipose tissue formation through stabilization of WTAP RNA methyltransferase.
Journal: EMBO J | Authors: Xixi Tao | Species: mouse | Application: WB - Development of a double shmiR lentivirus effectively targeting both BCL11A and ZNF410 for enhanced induction of fetal hemoglobin to treat β-hemoglobinopathies.
Journal: Mol Ther | Authors: Boya Liu | Species: human | Application: WB - Heteronemin Suppresses Lymphangiogenesis through ARF-1 and MMP-9/VE-Cadherin/Vimentin.
Journal: Biomedicines | Authors: Hsien-Lin Chen | Species: human | Application: WB - SWI/SNF complex-mediated ZNF410 cooperative binding maintains chromatin accessibility and enhancer activity
Journal: Cell Rep | Authors: Siyuan Xu | Species: human | Application: WB,ChIP - SWI/SNF complex-mediated ZNF410 cooperative binding maintains chromatin accessibility and enhancer activity
Journal: Cell Rep | Authors: Siyuan Xu | Species: human | Application: WB,ChIP - Heteronemin Suppresses Lymphangiogenesis through ARF-1 and MMP-9/VE-Cadherin/Vimentin.
Journal: Biomedicines | Authors: Hsien-Lin Chen | Species: human | Application: WB - Regulation of BCL11A DNA binding and expression in human erythrocyte precursor HUDEP-2 cells.
Journal: bioRxiv | Authors: Meigen Yu | Species: human | Application: WB
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