mTOR Substrates Antibody Kit PK30025 proteintech
$449.00
In stock
SKU
PK30025
| Catalog Number | PK30025 |
| Synonyms | United States |
| Applications | Target Dependent |
| Host / Isotype | Target Dependent |
| Antigen | Catalog No. Host, clonality Tested Reactivity Applications Volume |
| mTOR | 81670-1-RR Rabbit Monoclonal H, M, R WB, IP, IHC, IF/ICC, FC (Intra) 20 uL |
| Phospho-mTOR (Ser2448) | 80596-1-RR Rabbit Monoclonal H, M, R WB, IF/ICC 20 uL |
| Phospho-p70(S6K) (Thr389) | 82373-1-RR Rabbit Monoclonal H WB 20 uL |
| Phospho-4EBP1 (Thr37) | 81812-4-RR Rabbit Monoclonal H WB 20 uL |
| Phospho-RPS6 (Ser235/236) | 80130-2-RR Rabbit Monoclonal H, M, R WB 20 uL |
| Range | {{ptg:compareRange}} |
| Test | 20T, 100T, 500T |
The mammalian target of rapamycin (mTOR) forms the center of a powerful signaling pathway that regulates cell metabolism, proliferation, and survival. Its activation is contingent upon phosphorylation at the Ser2448 residue, which is typically mediated upstream by AKT. The activated mTOR can then phosphorylate multiple substrates downstream to control the various effector functions of the mTOR pathway. Phosphorylation of p70(S6K) at the Thr389 residue results in its full activation and promotion of cell proliferation and mRNA translation via subsequent phosphorylation of RPS6 at the Ser 235 and 236 residues. mTOR can also promote translation through phosphorylation of 4EBP1 at the Thr 37 and 46 residues. These phosphorylation events reduce the ability of 4EBP1 to bind to eIF4E, which in turn reduces the inhibition of cap-dependent translation. Standard Protocols Click here to view our standard protocols for various applications including WB, IP, IHC, IF, FC, and ELISA. Cited in Article as PK30025, mTOR Substrates Antibody Kit, Proteintech, IL, USA Documentation Datasheet mTOR Substrates Antibody Kit Datasheet
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