CoraLite®594 Anti-Human uPAR/CD87 Rabbit Recombinant Antibody CL594-98048 proteintech
$169.00
In stock
SKU
CL594-98048
| Catalog Number | CL594-98048 |
| Synonyms | PLAUR, UPAR, U PAR, MO3, CD87 |
| Host | Rabbit |
| Reactivity | human |
| Form | Liquid |
| Formulation | PBS, Azide, BSA |
| Applications | FC |
| Host / Isotype | Rabbit / IgG |
| Tested Applications — Positive FC detected in | PMA treated U-937 cells |
| Positive FC detected in | PMA treated U-937 cells |
| Flow Cytometry (FC) | FC : 5 ul per 10^6 cells in 100 μl suspension |
| Tested Reactivity | human |
| Class | Recombinant |
| Type | Antibody |
| Immunogen | Fusion Protein Predict reactive species |
| Full Name | PLAUR |
| Calculated Molecular Weight | 37 kDa |
| GenBank Accession Number | NM_002659.4 |
| Gene Symbol | uPAR |
| Gene ID (NCBI) | 5329 |
| RRID | AB_3673562 |
| Conjugate | CoraLite®594 Fluorescent Dye |
| Excitation/Emission Maxima Wavelengths | 588 nm / 604 nm |
| Excitation Laser | Yellow-Green Laser (561 nm) |
| Purification Method | Protein A purification |
| UNIPROT ID | Q03405-1 |
| Storage Buffer | PBS with 0.09% sodium azide and 0.5% BSA, pH 7.3. |
| Storage Conditions | Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment. |
| FC protocol for CL594 uPAR/CD87 antibody CL594-98048 | Download protocol |
| Citations | - |
| Isotype | IgG |
| Clonality | Recombinant |
| Clone Number | 240366G10 |
| Conjugation | CoraLite®594 |
uPAR, also known as CD87, is a highly glycosylated, GPI-anchored membrane protein. In addition to the membrane-anchored form, uPAR is released from the plasma membrane by cleavage of the GPI anchor and can be found as a soluble form (suPAR). uPAR contains three homologous domains (D1-D3) of which the N-terminal one (D1) represents the uPA-binding domain. After binding to uPAR, uPA cleaves plasminogen, generating the active protease plasmin which is involved in a wide variety of physiologic and pathologic processes. In addition to regulating proteolysis, uPAR has important function in cell adhesion, migration and proliferation. Studies reveal that uPAR expression is elevated during inflammation and tissue remodeling and in many human cancers, in which it frequently indicates poor prognosis. (PMID 20027185; 12461559) Protocols Product Specific Protocols FC protocol for CL594 uPAR/CD87 antibody CL594-98048 Download protocol Standard Protocols Click here to view our Standard Protocols
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