IRSp53 Monoclonal antibody 68348-1-Ig proteintech
$149.00
In stock
SKU
68348-1-Ig
| Catalog Number | 68348-1-Ig |
| Synonyms | BAI associated protein 2, BAI1 associated protein 2, BAIAP2, BAP2, Fas ligand associated factor 3, FLAF3, Insulin receptor substrate p53, IRS 58, IRSP53, IRSp53/58, Protein BAP2 |
| Host | Mouse |
| Reactivity | Human, Mouse, Rat, Rabbit |
| Reactivity | human, mouse, rat, rabbit |
| Form | Liquid |
| Formulation | PBS, Azide, Glycerol |
| Applications | WB, ELISA |
| Host / Isotype | Mouse / IgG1 |
| Tested Applications — Positive WB detected in | rabbit brain tissue, LNCaP cells, rabbit cerebellum tissue, rat brain tissue, mouse brain tissue |
| Recommended Dilutions — Western Blot (WB) | WB : 1:5000-1:50000 |
| Positive WB detected in | rabbit brain tissue, LNCaP cells, rabbit cerebellum tissue, rat brain tissue, mouse brain tissue |
| Western Blot (WB) | WB : 1:5000-1:50000 |
| Tested Reactivity | Human, Mouse, Rat, Rabbit |
| Class | Monoclonal |
| Type | Antibody |
| Immunogen | CatNo: Ag25161 Product name: Recombinant human BAIAP2 protein Source: e coli. -derived, PET28a Tag: 6*His Domain: 1-300 aa of BC014020 Sequence: MSLSRSEEMHRLTENVYKTIMEQFNPSLRNFIAMGKNYEKALAGVTYAAKGYFDALVKMGELASESQGSKELGDVLFQMAEVHRQIQNQLEEMLKSFHNELLTQLEQKVELDSRYLSAALKKYQTEQRSKGDALDKCQAELKKLRKKSQGSKNPQKYSDKELQYIDAISNKQGELENYVSDGYKTALTEERRRFCFLVEKQCAVAKNSAAYHSKGKELLAQKLPLWQQACADPSKIPERAVQLMQQVASNGATLPSALSASKSNLVISDPIPGAKPLPVPPELAPFVGRMSAQESTPIMN Predict reactive species |
| Full Name | BAI1-associated protein 2 |
| Calculated Molecular Weight | 61 kDa |
| Observed Molecular Weight | 53 kDa |
| GenBank Accession Number | BC014020 |
| Gene Symbol | IRSp53 |
| Gene ID (NCBI) | 10458 |
| RRID | AB_3085071 |
| Conjugate | Unconjugated |
| Purification Method | Protein G purification |
| UNIPROT ID | Q9UQB8 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA. |
| WB protocol for IRSp53 antibody 68348-1-Ig | Download protocol |
| Citations | - |
| Dilutions | WB : 1:5000-1:50000 |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Clone Number | 1D4G1 |
| Conjugation | Unconjugated |
IRSp53 (also known as BAIAP2) is a multi-domain adaptor protein that originally identified as a 58/53-kDa substrate of insulin-receptor kinase in the hamster (PMID: 10332026). As a BAI1-binding protein, IRSp53 plays an important role in linking between membrane and cytoskeleton in the process of neuronal growth (PMID: 10343108). IRSp53 is necessary for Cdc42-mediated reorganization of the actin cytoskeleton and for Rac1-mediated membrane ruffling. Alternatively spliced isoforms of IRSp53 exist. IRSp53 has been implicated in several psychiatric disorders, including autism spectrum disorders (ASDs), schizophrenia, and attention deficit/hyperactivity disorder (ADHD) (PMID: 26275848). Protocols Product Specific Protocols WB protocol for IRSp53 antibody 68348-1-Ig Download protocol Standard Protocols Click here to view our Standard Protocols
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