Brevican Polyclonal antibody 19017-1-AP proteintech
$149.00
In stock
SKU
19017-1-AP
| Catalog Number | 19017-1-AP |
| Synonyms | BCAN, UNQ2525/PRO6018, CSPG7, Brevican core protein, Brain-enriched hyaluronan-binding protein |
| Host | Rabbit |
| Reactivity | human, mouse, rat |
| Form | Liquid |
| Formulation | PBS, Azide, Glycerol |
| Applications | WB, IHC, IF, ELISA |
| Applications | WB, IHC, ELISA |
| Host / Isotype | Rabbit / IgG |
| Tested Applications — Positive WB detected in | human brain tissue, COLO 320 cells, SH-SY5Y cells, Y79 cells |
| Tested Applications — Positive IHC detected in | human cerebellum tissue, mouse brain tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Recommended Dilutions — Western Blot (WB) | WB : 1:500-1:2000 |
| Recommended Dilutions — Immunohistochemistry (IHC) | IHC : 1:50-1:500 |
| Positive WB detected in | human brain tissue, COLO 320 cells, SH-SY5Y cells, Y79 cells |
| Positive IHC detected in | human cerebellum tissue, mouse brain tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Western Blot (WB) | WB : 1:500-1:2000 |
| Immunohistochemistry (IHC) | IHC : 1:50-1:500 |
| Tested Reactivity | human, mouse, rat |
| Cited Reactivity | human, rat |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | CatNo: Ag13552 Product name: Recombinant human BCAN protein Source: e coli. -derived, PGEX-4T Tag: GST Domain: 23-350 aa of BC010571 Sequence: LEGDSSEDRAFRVRIAGDAPLQGVLGGALTIPCHVHYLRPPPSRRAVLGSPRVKWTFLSRGREAEVLVARGVRVKVNEAYRFRVALPTYPASLTDVSLALNELRPNDSGIYRCEVQHGIDDSSDAVEVKVKGVVFLYREGSARYAFSFSGAQEACARIGAHIATPEQLYAAYLGGYEQCDAGWLSDQTVRYPIQTPREACYGDMDGFPGVRNYGVVDPDDLYDVYCYAEDLNGELFLGDPPEKLTLEEARAYCQERGAEIATTGQLYAAWDGGLDHCSPGWLADGSVRYPIVTPSQRCGGGLPGVKTLFLFPNQTGFPNKHSRFNVY Predict reactive species |
| Full Name | brevican |
| Calculated Molecular Weight | 99 kDa |
| Observed Molecular Weight | 145 kDa, 72kDa, 80 kDa |
| GenBank Accession Number | BC010571 |
| Gene Symbol | BCAN |
| Gene ID (NCBI) | 63827 |
| RRID | AB_10643526 |
| Conjugate | Unconjugated |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | Q96GW7 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA. |
| IHC protocol for Brevican antibody 19017-1-AP | Download protocol |
| WB protocol for Brevican antibody 19017-1-AP | Download protocol |
| rat | IF Theranostics Biomimetic core-shell GelMA microspheres co-delivering ANXA1, NGF, and fibronectin enable phase-matched immunomodulation and neurorepair after spinal cord injury. Authors - Youjun Liu View Article |
| Human | Mol Psychiatry Molecular profiling of the hippocampus of children with autism spectrum disorder Authors - Lindsay E Rexrode View Article |
| Citations | 6 |
| Dilutions | WB : 1:500-1:2000 IHC : 1:50-1:500 |
| Isotype | IgG |
| Clonality | Polyclonal |
| Clone Number | - |
| Conjugation | Unconjugated |
Brevican is a brain-specific proteoglycan belonging to the aggrecan family that share a number of structural features. Brevican contains a hyaluronic acid-binding domain in its N-terminus and a lectin-like domain in its C-terminus. Expression of brevican is highly specific in the brain and increases as the brain develops. It may play a role in maintaining the extracellular environment of mature brain as a major constituent of the adult brain extracellular matrix (PMID:9117262). Brevican core protein exists as a 145 kDa full-length form and a 80 kDa N terminally truncated form (PMID: 8144512). This antibody can recognize the 72 kDa isoform of target. Protocols Product Specific Protocols IHC protocol for Brevican antibody 19017-1-AP Download protocol WB protocol for Brevican antibody 19017-1-AP Download protocol Standard Protocols Click here to view our Standard Protocols
Publications
- Retrosplenial Cortical Reorganization During Late Adolescence Introduces Instability of Episodic Memory Circuits
Journal: Res Sq | Authors: Jelena Radulovic - Subregion-specific perineuronal net remodelling in the dorsal hippocampus drives vulnerability and resilience to chronic stress: The role of venlafaxine treatment.
Journal: Br J Pharmacol | Authors: Paola Brivio - The Role of Meprins on the Brain Extracellular Matrix and Perineuronal Nets.
Journal: FASEB J | Authors: Simon Kreiselmaier - Retrosplenial cortical reorganization during late adolescence introduces instability of contextual memory circuits.
Journal: PLoS Biol | Authors: Hui Zhang - Biomimetic core-shell GelMA microspheres co-delivering ANXA1, NGF, and fibronectin enable phase-matched immunomodulation and neurorepair after spinal cord injury.
Journal: Theranostics | Authors: Youjun Liu | Species: rat | Application: IF - Molecular profiling of the hippocampus of children with autism spectrum disorder
Journal: Mol Psychiatry | Authors: Lindsay E Rexrode | Species: Human
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