BICD2 Polyclonal antibody 29603-1-AP proteintech
$149.00
In stock
SKU
29603-1-AP
| Catalog Number | 29603-1-AP |
| Synonyms | Bic D 2, Bic-D 2, KIAA0699, Protein bicaudal D homolog 2 |
| Host | Rabbit |
| Reactivity | human, mouse, rat |
| Form | Liquid |
| Formulation | PBS, Azide, Glycerol |
| Applications | WB, IHC, ELISA |
| Host / Isotype | Rabbit / IgG |
| Tested Applications — Positive WB detected in | A549 cells, Hela cells, Jurkat cells, K-562 cells, MCF-7 cells |
| Tested Applications — Positive IHC detected in | human stomach cancer tissue, human ovary cancer tissue, mouse stomach tissue, mouse testis tissue, rat stomach tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Recommended Dilutions — Western Blot (WB) | WB : 1:1000-1:4000 |
| Recommended Dilutions — Immunohistochemistry (IHC) | IHC : 1:250-1:1000 |
| Positive WB detected in | A549 cells, Hela cells, Jurkat cells, K-562 cells, MCF-7 cells |
| Positive IHC detected in | human stomach cancer tissue, human ovary cancer tissue, mouse stomach tissue, mouse testis tissue, rat stomach tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Western Blot (WB) | WB : 1:1000-1:4000 |
| Immunohistochemistry (IHC) | IHC : 1:250-1:1000 |
| Tested Reactivity | human, mouse, rat |
| Cited Reactivity | human |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | CatNo: Ag31279 Product name: Recombinant human BICD2 protein Source: e coli. -derived, PET28a Tag: 6*His Domain: 361-523 aa of BC073970 Sequence: GLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDRELLARLEKELKKVSDVAGETQGSLSVA Predict reactive species |
| Full Name | bicaudal D homolog 2 (Drosophila) |
| Calculated Molecular Weight | 855 aa, 97 kDa |
| Observed Molecular Weight | 93-96 kDa |
| GenBank Accession Number | BC073970 |
| Gene Symbol | BICD2 |
| Gene ID (NCBI) | 23299 |
| RRID | AB_2935474 |
| Conjugate | Unconjugated |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | Q8TD16 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA. |
| IHC protocol for BICD2 antibody 29603-1-AP | Download protocol |
| WB protocol for BICD2 antibody 29603-1-AP | Download protocol |
| human | WB Cell Rep COP9 signalosome and PRMT5 methylosome complexes are essential regulators of Lis1-dynein-based transport. Authors - Devanshi Gupta View Article |
| Citations | 2 |
| Dilutions | WB : 1:1000-1:4000 IHC : 1:250-1:1000 |
| Isotype | IgG |
| Clonality | Polyclonal |
| Clone Number | - |
| Conjugation | Unconjugated |
Protein bicaudal D homolog 2 (BICD2) acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates and stabilizes the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Facilitates the binding of RAB6A to the Golgi by stabilizing its GTP-bound form. Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport via its interaction with RAB6A and recruitment of the dynein-dynactin motor complex (PubMed:25962623). Protocols Product Specific Protocols IHC protocol for BICD2 antibody 29603-1-AP Download protocol WB protocol for BICD2 antibody 29603-1-AP Download protocol Standard Protocols Click here to view our Standard Protocols
Publications
- Programmable RNA N(6),2´-O-Dimethyladenosine Editing.
Journal: Adv Sci (Weinh) | Authors: Yang Li | Species: human | Application: WB - COP9 signalosome and PRMT5 methylosome complexes are essential regulators of Lis1-dynein-based transport.
Journal: Cell Rep | Authors: Devanshi Gupta | Species: human | Application: WB
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