IHC easy ® FBXW11 Ready-To-Use IHC Kit KHC1989 proteintech
$489.00
In stock
SKU
KHC1989
| Product name | IHCeasy FBXW11 Ready-To-Use IHC Kit |
| Synonyms | FBW1B, Fbw11, F-box/WD repeat-containing protein 1B, F-box/WD repeat-containing protein 11, F-box and WD repeats protein beta-TrCP2 |
| Reactivity | Human, Rat |
| Host / Isotype | United States |
| Sample type | FFPE tissue |
| Assay type | Immunohistochemistry |
| Primary antibody type | Mouse Monoclonal |
| Secondary antibody type | Polymer-HRP-Goat anti-Mouse |
| Component | Size Concentration |
| Antigen Retrieval Buffer | 100 mL 50× |
| Washing Buffer | 100 mL ×2 20× |
| Blocking Buffer | 5 mL RTU |
| Primary Antibody | 5 mL RTU |
| Secondary Antibody | 5 mL RTU |
| Chromogen Component A | 0.2 mL RTU |
| Chromogen Component B | 4 mL RTU |
| Signal Enhancer | 5 mL RTU |
| Counter Staining Reagent | 5 mL RTU |
| Mounting Media | 5 mL RTU |
| Datasheet | 1 Copy |
| Manual | 1 Copy |
| Storage Instructions | All the reagents are stored at 2-8°C. The kit is stable for 6 months from the date of receipt. |
FBXW11 (also known as HOS or β-TrCP2) is a member of F-box family proteins and plays critical role in regulating the ubiquitination of phosphorylated substrates. Abnormal expression of several FBXW11 is involved in the modulation of various biological events, such as cell cycle, differentiation, migration, inflammation, and apoptosis, through targeting multiple different substrates. For instance, FBXW11 could bind to the phosphorylated IκB and β-catenin, promoting their degradation via the ubiquitin-proteasome system. In addition, FBXW11 expression is markedly increased in mouse skin tumors and promotes tumor growth by activating the NF-κB signaling. Properties Storage Instructions All the reagents are stored at 2-8°C. The kit is stable for 6 months from the date of receipt. Synonyms FBW1B, Fbw11, F-box/WD repeat-containing protein 1B, F-box/WD repeat-containing protein 11, F-box and WD repeats protein beta-TrCP2 × Select download options English Czech Danish German Spanish Finnish French Hungarian Italian Lithuanian Dutch Norwegian-Bokmol Polish Portuguese Slovak Swedish Download
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