Recombinant Mouse IL-19 Protein (His-tag) servicebio GB300016-M-500μg
$50.00
In stock
SKU
GB300016-M-500娓璯
DESCRIPTION
SPECIFICATIONS
STORAGE
BACKGROUND
Interleukin- (IL-) 19, part of the IL-10 family, contributes to a range of diseases and disorders, such as asthma, endotoxic shock, uremia, psoriasis, and rheumatoid arthritis. IL-19 is expressed in several types of tumor cells, especially in squamous cell carcinoma of the skin, tongue, esophagus, and lung and invasive duct carcinoma of the breast. Interleukin (IL) 19 have been identified to play a role in the regulation of epidermal functions and in inflammation. IL-19 is a type of anti-inflammatory cytokine. IL19 expression was stimulated by diverse cellular stresses, including inhibition of the DNA replication checkpoint kinase ATR (ataxia telangiectasia and Rad3-related protein), oncogene expression, replicative exhaustion, oxidative stress, and DNA double-strand breaks. The molecular features at the IL19 locus may modestly alter the establishment of HIV-1 infection.
Data
| Gene Name Synonym | IL-19, IL19, Interleukin-19, ZMDA1, NG.1 |
| Species | Mouse |
| A ccession | Q8CJ70 |
| Source | HEK293 cells |
| Amino acid sequence | Leu25-Ala176 is expressed with a 10×His tag at the C terminus |
| Molecular Weight | 19.0 kDa |
| Purity | >95.0% as determined by SDS-PAGE |
| Endotoxin | <5 EU·mg -1 |
| Formulation | Lyophilized from sterile PBS, pH 7.4.Normally 5%-8% trehalose and mannitol are added as protectants before lyophilization. |
| Reconstitution | Dissolved in sterile water, it is recommended to add 0.1% HSA or BSA for long-term preservation. |
| Stability and Storage | 12 months from date of receipt at -20°C to -70°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for almost 6 months (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage. |
| SDS-PAGE | Bioactivity |
| Active Recombinant Mouse IL-19 Protein was determined by SDS-PAGE with Coomassie Blue, showing a band at 30-35 kDa. | Determined by its ability to induce STAT3 activation in Hela STAT3 LUC reporter cells.The ED50 for this effect is 10-50 ng/mL. |
For Research Use Only!
Ver. No.: V1.0-202102
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