Anti-THEM4 Rabbit pAb servicebio GB113055-100
$50.00
In stock
SKU
GB113055-100
Product Information
| Protein full name | Acyl-coenzyme A thioesterase THEM4 |
| Synonyms | Acyl-CoA thioesterase THEM4, Them4, Ctmp, Carboxyl-terminal modulator protein, Thioesterase superfamily member 4 |
| Uniprot ID | Q3UUI3 |
| Immunogen | Recombinant protein corresponding to Mouse THEM4 |
| Isotype | IgG |
| Predicted MW./Observed MW. | 26 kDa / 26 kDa |
| Purity | Affinity purification |
Applications
| Applications: WB | Species: Mouse, Rat |
| Dilution: 1: 300-1: 600 | Positive Tissue: liver |
Background
THEM4, also known as CTMP, binds specifically to the carboxy-terminal regulatory domain of PKB/Akt at the plasma membrane and acts as a negative regulator, reversing the phenotype of v-Akt-transformed cells. Hypermethylation of the THEM4 promoter and transcriptional downregulation of the gene has been reported in multiple glioblastomas, suggesting that epigenetic regulation of THEM4 may play a role in the progression of this cancer.
Images
WB analysis of THEM4(GB113055). Sample: Protein treated by RIPA Lysis Buffer (G2002). Blocking buffer: 3% Nonfat dry milk (GC310001) in TBST, RT, 1h. Primary antibody: 1: 600, 4℃ overnight. Secondary antibody: HRP conjugated Goat Anti-Rabbit lgG (H+L) (GB23303), 1: 5000, RT, 1h.
Storage
| Storage | Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.15% ProClin300, 100 μg/mL BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.
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