Anti-CD39/ENTPD1 Antibody, Rabbit Polyclonal sinobiological 109342-T32
$243.00
In stock
SKU
109342-T32
| Catalog No. | Size | Price (USD) |
| 109342-T32-100 | 100 µL | $251.64 |
General Information
| Product name | Anti-CD39/ENTPD1 Antibody, Rabbit Polyclonal |
| Validated applications | WB (FAQ Protocol) |
| Species reactivity | Reacts with: Mouse |
| Specificity | Mouse CD39/ENTPD1 |
| Immunogen | A synthetic peptide corresponding to the C-terminus of the Mouse CD39 |
| Preparation | Produced in rabbits immunized with a synthetic peptide corresponding to the C-terminus of the Mouse CD39, and purified by antigen affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | PBS, pH7.0 with 0.03% Proclin300 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-2610206B08Rik Antibody; Anti-ATP-DPH Antibody; Anti-Cd39 Antibody; Anti-E130009M23Rik Antibody; Anti-Entpd1 Antibody; Anti-NTPDase-1 Antibody
Image / Experimental Information
| Image 1 Description | Anti-CD39 rabbit polyclonal antibody at 1:500 dilution Lane A: Mouse kidney tissue lysate Whole Cell Lysate Lysates/proteins at 30 μg per lane. Secondary Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size:58 kDa Observed band size:95 kDa |
| Image 1 Alt Text | Mouse CD39 Western blot (WB) 38701 |
| Image 1 URL | Source image |
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Background Information
| Full Name | ectonucleoside triphosphate diphosphohydrolase 1 |
| Description | CD39, also known as ENTPD1, belongs to the GDA1/CD39 NTPase family. It is expressed primarily on activated lymphoid cells and can also be detected in endothelial tissues. The vascular isoform and the placental isoform II are present in both placenta and umbilical vein, whereas placental isoform I is present in placenta only. CD39 can hydrolyze both nucleoside triphosphates and diphosphates. It is the dominant ecto nucleotidase of vascular and placental trophoblastic tissues and appears to modulate the functional expression of type 2 purinergic (P2) G protein coupled receptors (GPCRs). CD39 transgenic mice exhibit impaired platelet aggregation, prolonged bleeding times, and resistance to systemic thromboembolism. There is a correlation between ATP hydrolysis and triglycerides in patients with chronic heart disease, suggesting a relationship between ATP diphosphohydrolase and thrombogenesis. In the nervous system, CD39 could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. |
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