| Catalog No. | Size | Price (USD) |
| 80049-T24-50 | 50 µL | $147.96 |
| 80049-T24-100 | 100 µL | $251.64 |
| 80049-T24-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-MMP-9 Antibody, Rabbit Polyclonal |
| Validated applications | ELISA (FAQ Protocol), IHC-P (FAQ Protocol) |
| Species reactivity | Reacts with: Rat |
| Specificity | Rat MMP-9 |
| Immunogen | Recombinant Rat MMP-9 / MMP9 Protein (Catalog#80049-R08H) |
| Preparation | Produced in rabbits immunized with purified, recombinant Rat MMP-9 / MMP9 (rR MMP-9 / MMP9; Catalog#80049-R08H; EDL96479.1; Met1-Pro708). MMP-9 / MMP9 specific IgG was purified by Rat MMP-9 / MMP9 affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-Mmp9 Antibody
Image / Experimental Information
| Image 1 Description | Immunochemical staining of rat MMP9 in rat spleen with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections). |
| Image 1 Alt Text | Rat MMP9/MMP-9/CLG4B Immunohistochemistry(IHC) 3110 |
| Image 1 URL | Source image |
Background Information
| Full Name | matrix metallopeptidase 9 |
| Description | Matrix metalloproteinases (MMPs) are neutral proteinases that are involved in the breakdown and remodeling of the extracellular matrix (ECM) under a variety of physiological and pathological conditions, such as morphogenesis, differentiation, angiogenesis, and tissue remodeling, as well as pathological processes including inflammation, arthritis, cardiovascular diseases, pulmonary diseases, and tumor invasion. MMP9, also known as 92-kDa gelatinase B/type IV collagenase, is secreted from neutrophils, macrophages, and some transformed cells, and is the most complex family member in terms of domain structure and regulation of its activity. It plays an important role in tissue remodeling in normal and pathological inflammatory processes. MMP-9 is a major secretion product of macrophages and a component of cytoplasmic granules of neutrophils and is particularly important in the pathogenesis of inflammatory, infectious, and neoplastic diseases in many organs including the lung. This enzyme is also secreted by lymphocytes and stromal cells upon stimulation by inflammatory cytokines, or upon delivery of bi-directional activation signals following integrin-mediated cell-cell or cell-extracellular matrix (ECM) contacts. Since the integrity of the tissue architecture is closely dependent on the delicate balance between MMPs and their inhibitors, excessive production of MMP-9 is linked to tissue damage and degenerative inflammatory disorders. As a consequence, regulation of gene transcription and tissue-specific expression of MMP-9 in normal and diseased states are being actively investigated to pave the way for new therapeutic targets. Besides, the dramatic overexpression of MMP-9 in cancer and various inflammatory conditions points to the molecular mechanisms controlling its expression as a potential target for eventual rational therapeutic intervention. |
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| Related Pathways |
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| References |
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title: Biosensing Intestinal Alkaline Phosphatase by Pregnancy Test Strips Based on Target-Triggered CRISPR-Cas12a Activity to Monitor Intestinal Inflammation.
authors: Zhenzhen Jia; Yujie Zhang; ...; Mingzhen Zhang
journal: Analytical Chemistry
date: 2023-09-20
pmid: 37668549
doi: 10.1021/acs.analchem.3c03099
cited_by_count: 4
techniques: CRISPR; Pregnancy Test (hCG) Assay; Stripping Membranes
bioz_score: 91
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