| Catalog No. | Size | Price (USD) |
| 90043-RP01-100 | 100 µL | $147.96 |
| 90043-RP01-200 | 200 µL | $251.64 |
| 90043-RP01-400 | 400 µL | $355.32 |
General Information
| Product name | Anti-HER3/ERBB3 Antibody, Rabbit Polyclonal |
| Validated applications | ELISA (FAQ Protocol) |
| Species reactivity | Reacts with: Rhesus |
| Specificity | Rhesus HER3/ERBB3 |
| Immunogen | Recombinant Rhesus HER3 / ErbB3 protein (Catalog#90043-K08H) |
| Preparation | Produced in rabbits immunized with purified, recombinant Rhesus HER3 / ErbB3 (rh ERBB3; Catalog#90043-K08H; XP_005571238.1 / XP_001113953.2; Met1-Thr643). Total IgG was purified by Protein A affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Background Information
| Full Name | erb-b2 receptor tyrosine kinase 3 |
| Description | ErbB3, also known as Her3(human epidermal growth factor receptor3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin binding domain but has not an active kinase domain., and therefore can not mediate the intracellular signal transduction through protein phosphorylation. However, its heterodimer with ErbB2 or other EGFR members responsible for tyrosine phosphorylation forms a receptor complex with high affinity, and initiates the related pathway which lead to cell proliferation or differentiation. ErbB3 has been shown to implicated in numerous cancers, including prostate, bladder, and breast tumors. This protein has different isoforms derived from alternative splicing variants, and among which, the secreted isoform lacking the intermembrane region modulates the activity of membrane-bound form. |
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| References |
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title: HER3 antigen-binding molecules
authors: Jerome Douglas Boyd-Kirkup; Piers Ingram; ...; Siyu Guan
date: 2023-10-10
cited_by_count: 0
techniques: Clone Assay; Modification; Sequencing
bioz_score: 91
