Rat B7-2/CD86 ELISA Kit sinobiological KIT80025

$400.00
In stock
SKU
KIT80025
Catalog No.SizePrice (USD)
KIT80025-11 Kit (96 Tests)$414.71

General Information

Product nameRat B7-2/CD86 ELISA Kit
SpecificityThis assay recognizes recombinant rat CD86.
ConjugateHRP
ShippingThis ELISA Kit is shipped at ambient temperature.
StorageUnopened Kit: Store at 2 - 8℃ Opened/Reconstituted Reagents: Please refer to CoA
Assay typeSolid Phase Sandwich ELISA (quantitative)
Sample typeRecombinant protein
Sensitivity4.4 pg/mL
Assay range7.8-500 pg/mL
Materials provided1. 96 well microplate coated with Capture Antibody 2. Detection Antibody conjugated to HRP 3. Standards 4. Wash Buffer Concentrate 5. Dilution Buffer Concentrate 6. Color Reagent A 7. Color Reagent B 8. Stop Solution
Product overviewThis Rat B7-2/CD86 ELISA Kit is an enzyme-linked immunosorbent assay for the quantitative measurement of Rat B7-2/CD86 protein in Recombinant protein . It contains recombinant Rat B7-2/CD86, and antibodies raised against the recombinant protein. This ELISA kit is complete and ready-to-use.

Synonyms: B7-2 ELISA Kit, Rat

Image / Experimental Information

Image 1 DescriptionThis standard curve is only for demonstration purposes. A standard curve should be generated for each assay.
Image 1 Alt TextRat CD86/B7-2 ELISA Kit Standard Curve 142
Image 1 URLSource image
Image 2 DescriptionThis standard curve is only for demonstration purposes. A standard curve should be generated for each assay.
Image 2 Alt TextRat CD86/B7-2 ELISA Kit Specificity 145
Image 2 URLSource image

Background Information

Full NameCD86 antigen
DescriptionCD86, also known as B-lymphocyte activation antigen B7-2 (referred to as B70), is a member of the cell surface immunoglobulin superfamily. B7-2 exists predominantly as a monomer on cell surfaces and interacts with two co-stimulatory receptors CD28 and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) expressed on T cells, and thus induces the signal pathways which regulate T cell activation and tolerance, cytokine production, and the generation of CTL. It is indicated that contacts between B and T helper cells mediated by CD86 encourage signals for the proliferation and IgG secretion of normal B cells and B cell lymphomas. A recent study has revealed that CD86 also promotes the generation of a mature APC repertoire and promotes APC function and survival. CD86 has an important role in chronic hemodialysis, allergic pulmonary inflammation, arthritis, and antiviral responses, and thus is regarded as a promising candidate for immune therapy.
Research Areas
  • Cancer Drug Targets
Tags
  • Cancer Immunotherapy
  • Co-inhibitory Immune Checkpoint Targets
  • Immune Checkpoint
  • Immune Checkpoint Detection: Antibodies
  • Immune Checkpoint Detection: ELISA Antibodies
  • Immune Checkpoint Detection: FCM Antibodies
  • Immune Checkpoint Detection: IP Antibodies
  • Immune Checkpoint Detection: WB Antibodies
  • Immune Checkpoint Proteins
  • Immune Checkpoint Targets
  • Immunotherapy
  • Targeted Therapy
References
  1. Chen YQ, et al. (2006) CD28/CTLA-4--CD80/CD86 and ICOS--B7RP-1 costimulatory pathway in bronchial asthma. Allergy. 61(1): 15-26.
  2. Rau FC, et al. (2009) B7-1/2 (CD80/CD86) direct signaling to B cells enhances IgG secretion. J Immunol. 183(12): 7661-71.
  3. Dai ZS, et al. (2009) Defective expression and modulation of B7-2/CD86 on B cells in B cell chronic lymphocytic leukemia. Int J Hematol. 89(5): 656-63.

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