Rat C1qR1/CD93 ELISA Kit sinobiological KIT80207

$714.00
In stock
SKU
KIT80207
Catalog No.SizePrice (USD)
KIT80207-11 Kit (96 Tests)$740.55

General Information

Product nameRat C1qR1/CD93 ELISA Kit
SpecificityThis assay recognizes both recombinant and natural Rat CD93.
ConjugateHRP
ShippingThis ELISA Kit is shipped at ambient temperature.
StorageUnopened Kit: Store at 2 - 8℃ Opened/Reconstituted Reagents: Please refer to CoA
Assay typeSolid Phase Sandwich ELISA (quantitative)
Sample typeSerum
Sensitivity9.56 pg/mL
Assay range18.75-1200 pg/mL
Materials provided1. 96 well microplate coated with Capture Antibody 2. Detection Antibody conjugated to HRP 3. Standards 4. Wash Buffer Concentrate 5. Dilution Buffer Concentrate 6. Color Reagent A 7. Color Reagent B 8. Stop Solution
Product overviewThis Rat C1qR1/CD93 ELISA Kit is an enzyme-linked immunosorbent assay for the quantitative measurement of Rat C1qR1/CD93 protein in Serum . It contains recombinant Rat C1qR1/CD93, and antibodies raised against the recombinant protein. This ELISA kit is complete and ready-to-use.
InterferencePreparations of human CD93 at 50 ng/mL in a mid-range recombinant rat CD93 control were assayed for interference. No significant interference was observed.

Synonyms: C1qr1 ELISA Kit, Rat; C1qRp ELISA Kit, Rat; Cd93 ELISA Kit, Rat; Ly68 ELISA Kit, Rat

Image / Experimental Information

Image 1 DescriptionThis standard curve is only for demonstration purposes. A standard curve should be generated for each assay.
Image 1 Alt TextRat CD93/C1qR ELISA Kit Standard Curve 17206
Image 1 URLSource image
Image 2 DescriptionThis standard curve is only for demonstration purposes. A standard curve should be generated for each assay.
Image 2 Alt TextRat CD93/C1qR ELISA Kit Specificity 17220
Image 2 URLSource image

Background Information

Full NameCD93 molecule
DescriptionCD93 or C1q receptor 1 (C1qR) is an about 120 kDa O-sialoglycoprotein that within the hematopoietic system is selectively expressed on cells of the myeloid lineage. CD93/C1qR is a highly glycosylated transmembrane protein expressed on monocytes, neutrophils, endothelial cells, and stem cells. CD93 was originally identified as a myeloid cell-surface marker and subsequently associated with an ability to modulate phagocytosis of suboptimally opsonized immunoglobulin G and complement particles in vitro. CD93/C1qR, a receptor expressed during early B-cell development, is reinduced during plasma-cell differentiation. High CD93/CD138 expression was restricted to antibody-secreting cells both in T-dependent and T-independent responses as naive, memory, and germinal-center B cells remained CD93-negative. CD93 was expressed on (pre)plasmablasts/plasma cells, including long-lived plasma cells that showed decreased cell cycle activity, high levels of isotype-switched Ig secretion, and modification of the transcriptional network. CD93 is important for the maintenance of plasma cells in bone marrow niches.
References
  1. Bohlson SS, et al. (2005) CD93 is rapidly shed from the surface of human myeloid cells and the soluble form is detected in human plasma. J Immunol. 175(2): 1239-47.
  2. Norsworthy PJ, et al. (2004) Murine CD93 (C1qRp) contributes to the removal of apoptotic cells in vivo but is not required for C1q-mediated enhancement of phagocytosis. J Immunol. 172(6): 3406-14.
  3. Chevrier S, et al. (2009) CD93 is required for maintenance of antibody secretion and persistence of plasma cells in the bone marrow niche. Proc Natl Acad Sci U S A. 106(10): 3895-900.

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