| Catalog No. | Size | Price (USD) |
| KIT40592G-1 | 1 Kit (96 Tests) | $740.55 |
General Information
| Product name | SARS-CoV-2 Omicron (XBB.1.5) variant Spike RBD ELISA Kit |
| Specificity | This assay recognizes recombinant SARS-CoV-2 Omicron (XBB.1.5) variant Spike RBD. |
| Conjugate | HRP |
| Shipping | This ELISA Kit is shipped at ambient temperature. |
| Storage | Unopened Kit: Store at 2 - 8℃ Opened/Reconstituted Reagents: Please refer to CoA |
| Assay type | Solid Phase Sandwich ELISA (quantitative) |
| Sample type | Recombinant protein |
| Sensitivity | 0.15 pg/mL |
| Assay range | 7.03-450 pg/mL |
| Materials provided | 1. 96 well microplate coated with Capture Antibody 2. Detection Antibody conjugated to HRP 3. Standards 4. Wash Buffer Concentrate 5. Dilution Buffer Concentrate 6. Color Reagent A 7. Color Reagent B 8. Stop Solution |
| Product overview | This SARS-CoV-2 Omicron (XBB.1.5) variant Spike RBD ELISA Kit is an enzyme-linked immunosorbent assay for the quantitative measurement of SARS-CoV-2 Coronavirus spike protein in Recombinant protein . It contains recombinant SARS-CoV-2 Coronavirus spike, and antibodies raised against the recombinant protein. This ELISA kit is complete and ready-to-use. |
Image / Experimental Information
| Image 1 Description | This standard curve is only for demonstration purposes. A standard curve should be generated for each assay. |
| Image 1 Alt Text | SARS-CoV-2 Coronavirus spike ELISA Kit Standard Curve 37828 |
| Image 1 URL | Source image |
Background Information
| Description | The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. Known receptors bind S1 are ACE2 (angiotensin-converting enzyme 2), DPP4 (dipeptidyl peptidase-4), APN (aminopeptidase N), CEACAM (carcinoembryonic antigen-related cell adhesion molecule), Sia (sialic acid), O-ac Sia (O-acetylated sialic acid). The spike is essential for both host specificity and viral infectivity. The term 'peplomer' is typically used to refer to a grouping of heterologous proteins on the virus surface that function together. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. It's been reported that SARS-CoV-2 (COVID-19 coronavirus, 2019-nCoV) can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion. The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. The main functions for the Spike protein are summarized as: Mediate receptor binding and membrane fusion; Defines the range of the hosts and specificity of the virus; Main component to bind with the neutralizing antibody; Key target for vaccine design; Can be transmitted between different hosts through gene recombination or mutation of the receptor binding domain (RBD), leading to a higher mortality rate. |
| References |
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title: Safety and Immunogenicity of aerosolized adenovirus-vectored COVID-19 vaccine and intramuscular mRNA vaccine bivalent boosters: a randomized open-label clinical trial
authors: Shipo Wu; Jianying Huang; ...; Lihua Hou
journal: Nature Communications
date: 2025-08-07
pmid: 40775215
doi: 10.1038/s41467-025-62698-7
cited_by_count: 1
techniques: BIA-KA; Labeling
bioz_score: 93
title: An open-label study on the safety and immunogenicity of a PD-1-enhanced DNA vaccine used as a T cell booster for COVID-19
authors: Yik Chun Wong; Derek Hoi Hang Ho; ...; Ivan Fan Ngai Hung
journal: EBioMedicine
date: 2025-05-01
pmid: 40245494
doi: 10.1016/j.ebiom.2025.105699
cited_by_count: 1
techniques: Binding Assay; Clinical Proteomics; Enzyme-linked Immunosorbent Assay; Recombinant
bioz_score: 93
title: Estimating SARS-CoV-2 Omicron XBB.1.5 Spike-Directed Functional Antibody Levels From an Anti-Receptor Binding Domain Wuhan-Hu-1-Based Commercial Immunoassay Results.
authors: Ángela Sánchez-Simarro; Enric Cuevas-Ferrando; ...; David Navarro
journal: Journal of medical virology
date: 2025-01-15
pmid: 39812228
doi: 10.1002/jmv.70130
cited_by_count: 0
techniques: Activation Assay; Flow Cytometry; Membrane; Quantitation Assay; Recombinant
bioz_score: 94
