Human EGFR ELISA Kit sinobiological KIT10001

$400.00
In stock
SKU
KIT10001
Catalog No.SizePrice (USD)
KIT10001-11 Kit (96 Tests)$414.71

General Information

Product nameHuman EGFR ELISA Kit
SpecificityThis assay recognizes both recombinant and natural Human EGFR.
ConjugateHRP
ShippingThis ELISA Kit is shipped at ambient temperature.
StorageUnopened Kit: Store at 2 - 8℃ Opened/Reconstituted Reagents: Please refer to CoA
Assay typeSolid Phase Sandwich ELISA (quantitative)
Sample typeSerum
Sensitivity3.16 pg/mL
Assay range43.75-2800 pg/mL
Materials provided1. 96 well microplate coated with Capture Antibody 2. Detection Antibody conjugated to HRP 3. Standards 4. Wash Buffer Concentrate 5. Dilution Buffer Concentrate 6. Color Reagent A 7. Color Reagent B 8. Stop Solution
Product overviewThis Human EGFR ELISA Kit is an enzyme-linked immunosorbent assay for the quantitative measurement of Human EGFR protein in Serum . It contains recombinant Human EGFR, and antibodies raised against the recombinant protein. This ELISA kit is complete and ready-to-use.
InterferencePreparations of human EGF at 10 ng/mL in a mid-range recombinant human EGFR control were assayed for interference. No significant interference was observed.

Synonyms: ERBB ELISA Kit, Human; ERBB1 ELISA Kit, Human; ERRP ELISA Kit, Human; HER1 ELISA Kit, Human; mENA ELISA Kit, Human; NISBD2 ELISA Kit, Human; PIG61 ELISA Kit, Human

Image / Experimental Information

Image 1 DescriptionThis standard curve is only for demonstration purposes. A standard curve should be generated for each assay.
Image 1 Alt TextHuman EGFR/HER1 ELISA Kit Standard Curve 30
Image 1 URLSource image
Image 2 DescriptionThis standard curve is only for demonstration purposes. A standard curve should be generated for each assay.
Image 2 Alt TextHuman EGFR/HER1 ELISA Kit Specificity 227
Image 2 URLSource image

Background Information

Full Nameepidermal growth factor receptor
DescriptionAs a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently.
Research Areas
  • Cancer Drug Targets
  • Receptor Tyrosine Kinases (RTKs)
Related Pathways
  • EGFR Signaling Pathway
  • Jak-Stat Signaling Pathway
Tags
  • Cancer Immunotherapy
  • Immune Checkpoint
  • Immunotherapy
  • Targeted Therapy
References
  1. Schlessinger, J. (2000) Cell signaling by receptor tyrosine kinases. Cell 103(2): 211-25.
  2. Giaccone, G. (2005) HER1/EGFR-targeted agents: predicting the future for patients with unpredictable outcomes to therapy. Ann. Oncol. 16(4): 538-48.
  3. Yarden, Y., et al. (2001) Untangling the ErbB signalling network. Nat. Rev. Mol. Cell. Biol. 2(2): 127-37.

title: Integrative gene ontology and network analysis of coronary artery disease associated genes suggests potential role of ErbB pathway gene EGFR
authors: Madankumar Ghatge; Jiny Nair; ...; Rajani Kanth Vangala
journal: Molecular medicine reports
date: 2018-03-01
pmid: 29328373
doi: 10.3892/mmr.2018.8393
pmcid: 5802197
cited_by_count: 8
techniques: Biomarker Assay; Enzyme-linked Immunosorbent Assay; Expressing; Filtration; Incubation; Selection; Software; Western Blot
bioz_score: 94

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