| Catalog No. | Size | Price (USD) |
| 11150-MM06-C-25 | 25 Tests | $133.30 |
| 11150-MM06-C-100 | 100 Tests | $414.71 |
General Information
| Product name | Anti-CD69 Antibody (PerCP), Mouse Monoclonal |
| Validated applications | FCM (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human CD69 |
| Immunogen | Recombinant Human CD69 Protein (Catalog#11150-H08H) |
| Preparation | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD69 (rh CD69; Catalog#11150-H08H; NP_001772.1; Ser62-Lys199) and conjugated with PerCP under optimum conditions, the unreacted PerCP was removed. |
| Source | Monoclonal Mouse IgG1 Clone #06 |
| Purification | Protein A |
| Formulation | PBS solution containing 0.5% BSA and 0.03%ProClin300 |
| Concentration | 5 μl/Test, 0.1 mg/ml |
| Conjugate | PerCP |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! |
Synonyms: Anti-AIM Antibody; Anti-BL-AC/P26 Antibody; Anti-CLEC2C Antibody; Anti-EA1 Antibody; Anti-GP32/28 Antibody; Anti-MLR-3 Antibody
Image / Experimental Information
| Image 1 Description | Flow cytometric analysis of Human CD69 expression on PHA-activated human whole blood lymphocytes. Cells were stained with PerCP-conjugated anti-Human CD69. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of viable lymphocytes. |
| Image 1 Alt Text | Human CD69 Flow Cytometry (FC) 31539 |
| Image 1 URL | Source image |
Background Information
| Full Name | CD69 molecule |
| Description | Early activation antigen CD69, also known as activation inducer molecule (AIM), is a single-pass type II membrane protein. Recently, cDNA clones encoding human and mouse CD69 were isolated and showed CD69 to be a member of the C-type lectin superfamily. It is one of the earliest cell surface antigens expressed by T cells following activation. Once expressed, CD69 acts as a costimulatory molecule for T cell activation and proliferation. In addition to mature T cells, CD69 is inducibly expressed by immature thymocytes, B cells, natural killer (NK) cells, monocytes, neutrophils and eosinophils, and is constitutively expressed by mature thymocytes and platelets. CD69 is involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets. The structure, chromosomal localization, expression and function of CD69 suggest that it is likely a pleiotropic immune regulator , potentially important in the activation and differentiation of a wide variety of hematopoietic cells. This membrane molecule transiently expresses on activated lymphocytes, and its selective expression in inflammatory infiltrates suggests that it plays a role in the pathogenesis of inflammatory diseases. CD69 plays a crucial role in the pathogenesis of allergen-induced eosinophilic airway inflammation and hyperresponsiveness and that CD69 could be a possible therapeutic target for asthmatic patients. |
| References |
|
