| Catalog No. | Size | Price (USD) |
| 50068-R313-P-25 | 25 Tests | $103.68 |
| 50068-R313-P-100 | 100 Tests | $325.84 |
General Information
| Product name | Recombinant Anti-B7-2/CD86 Antibody (PE), Rabbit Monoclonal |
| Validated applications | FCM (FAQ Protocol) |
| Species reactivity | Reacts with: Mouse |
| Specificity | Mouse B7-2/CD86 |
| Immunogen | Recombinant Mouse CD86 Protein (Catalog#50068-M08H) |
| Preparation | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse CD86 (rM CD86; Catalog#50068-M08H; NP_062261.3; Met1-Glu245) and conjugated with PE under optimum conditions, the unreacted PE was removed. |
| Source | Monoclonal Rabbit IgG Clone #313 |
| Purification | Protein A |
| Formulation | PBS solution containing 0.5% BSA and 0.03%ProClin300 |
| Concentration | 5 μl/Test, 0.1 mg/ml |
| Conjugate | PE |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! |
Synonyms: Anti-B7 Antibody; Anti-B7-2 Antibody; Anti-B7.2 Antibody; Anti-B70 Antibody; Anti-Cd28l2 Antibody; Anti-Cd86 Antibody; Anti-CLS1 Antibody; Anti-ETC-1 Antibody; Anti-Ly-58 Antibody; Anti-Ly58 Antibody; Anti-MB7 Antibody; Anti-MB7-2 Antibody; Anti-TS/A-2 Antibody
Image / Experimental Information
| Image 1 Description | Flow cytometric analysis of Mouse-CD86 expression on LPS-stimulated BABL/c splenocytes.Cells were stained with PE-conjugated anti-Mouse-CD86. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| Image 1 Alt Text | Mouse CD86 Flow Cytometry (FC) 35890 |
| Image 1 URL | Source image |
Background Information
| Full Name | CD86 antigen |
| Description | CD86, also known as B-lymphocyte activation antigen B7-2 (referred to as B70), is a member of the cell surface immunoglobulin superfamily. B7-2 exists predominantly as a monomer on cell surfaces and interacts with two co-stimulatory receptors CD28 and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) expressed on T cells, and thus induces the signal pathways which regulate T cell activation and tolerance, cytokine production, and the generation of CTL. It is indicated that contacts between B and T helper cells mediated by CD86 encourage signals for the proliferation and IgG secretion of normal B cells and B cell lymphomas. A recent study has revealed that CD86 also promotes the generation of a mature APC repertoire and promotes APC function and survival. CD86 has an important role in chronic hemodialysis, allergic pulmonary inflammation, arthritis, and antiviral responses, and thus is regarded as a promising candidate for immune therapy. |
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