| Catalog No. | Size | Price (USD) |
| 80025-R053-100 | 100 µL | $251.64 |
General Information
| Product name | Recombinant Anti-B7-2/CD86 Antibody, Rabbit Monoclonal |
| Validated applications | ELISA (FAQ Protocol) |
| Species reactivity | Reacts with: Rat |
| Specificity | Rat B7-2/CD86 |
| Immunogen | Recombinant Rat B7-2/CD86 Protein (Catalog#80025-R08H) |
| Preparation | This antibody was obtained from a rabbit immunized with purified, recombinant Rat B7-2/CD86 (rR B7-2/CD86; Catalog#80025-R08H; NP_064466.1; Met1-Ile250). |
| Source | Monoclonal Rabbit IgG Clone #053 |
| Purification | Protein A |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-B7-2 Antibody
Background Information
| Full Name | CD86 antigen |
| Description | CD86, also known as B-lymphocyte activation antigen B7-2 (referred to as B70), is a member of the cell surface immunoglobulin superfamily. B7-2 exists predominantly as a monomer on cell surfaces and interacts with two co-stimulatory receptors CD28 and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) expressed on T cells, and thus induces the signal pathways which regulate T cell activation and tolerance, cytokine production, and the generation of CTL. It is indicated that contacts between B and T helper cells mediated by CD86 encourage signals for the proliferation and IgG secretion of normal B cells and B cell lymphomas. A recent study has revealed that CD86 also promotes the generation of a mature APC repertoire and promotes APC function and survival. CD86 has an important role in chronic hemodialysis, allergic pulmonary inflammation, arthritis, and antiviral responses, and thus is regarded as a promising candidate for immune therapy. |
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