| Catalog No. | Size | Price (USD) |
| 16358-H25H-20 | 20 µg | $737.59 |
| 16358-H25H-100 | 100 µg | $1,552.20 |
| 16358-H25H-500 | 500 µg | $7,100.43 |
General Information
| Formulation | Supplied as sterile 50 mM Hepes, 150 mM NaCl, 10% Trehalose, pH 7.2. Please contact us for any concerns or special requirements. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method |
| Shipping | It is supplied and shipped as liquid with dry ice. |
| Stability & Storage | Samples are stable for up to twelve months from date of receipt at -70℃. Store it under sterile conditions at -70℃ or lower. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
| Activity | Immobilized Recombinant Human Claudin-4-VLP Protein (Cat:16358-H25H) at 5 μg/mL (100 μL/well) can bind Anti-Human Claudin-4 Monoclonal antibody, Human IgG1, the EC 50 is 10-30 ng/mL. |
| Protein Construction | A DNA sequence encoding the Human CLDN4-VLP (Full Length) (O14493) (Met1-Val209) was fused with a flag tag at the C-terminus. |
| Expressed Host | HEK293 Cells |
| Species | Human |
| Predicted N Terminal | Met 1 |
| Molecule Mass | The recombinant Human CLDN4-VLP (Full Length) consisting of 222 amino acids and has a calculated molecular mass of 23.39 kDa. |
Synonyms: CPE-R Protein, Human; CPER Protein, Human; CPETR Protein, Human; CPETR1 Protein, Human; hCPE-R Protein, Human; WBSCR8 Protein, Human
Image / Experimental Information
| Image 1 Description | Immobilized Recombinant Human Claudin-4-VLP Protein (Cat:16358-H25H) at 5 μg/mL (100 μL/well) can bind Anti-Human Claudin-4 Monoclonal antibody, Human IgG1, the EC 50 is 10-30 ng/mL. |
| Image 1 Alt Text | Human Claudin-4/CLDN4 Protein 40490 |
| Image 1 URL | Source image |
Background Information
| Full Name | claudin 4 |
| Description | CLDN4 (encoding claudin-4), a cell tight junction (TJ) protein, is highly expressed in human epithelial ovarian carcinomas (EOC) but undetectable in normal ovaries. Claudins form a large family of tight junction proteins that have essential roles in the control of paracellular ion flux and the maintenance of cell polarity. CLDN4 has been identified as a specific receptor for C terminus of Clostridium perfringens enterotoxin (C-CPE), a nontoxic molecule that may disrupt TJ barrier function and enhance cellular absorption. Claudin-4, encoding a protein for tight junction formation and function, is highly overexpressed in pancreatic ductal adenocarcinoma and is also associated with invasive adenocarcinomas arising in intraductal papillary mucinous neoplasms of the pancreas. Claudin-4 expression is associated with neoplastic progression of intraductal papillary mucinous neoplasms and, especially, with a distinct pathway to intestinal differentiation. CLDN4 is a tight junction protein involved in blood-brain barrier integrity. |
