Anti-CD89/FCAR Antibody, Rabbit Polyclonal sinobiological 10414-T16
$243.00
In stock
SKU
10414-T16
| Catalog No. | Size | Price (USD) |
| 10414-T16-100 | 100 µL | $251.64 |
General Information
| Product name | Anti-CD89/FCAR Antibody, Rabbit Polyclonal |
| Validated applications | ELISA (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human CD89/FCAR |
| Immunogen | Recombinant Human CD89 Protein (Catalog#10414-H08H) |
| Preparation | Produced in rabbits immunized with purified, recombinant Human CD89 (rh CD89; Catalog#10414-H08H; NP_001991.1; Met1-Asn227). CD89 specific IgG was purified by Human CD89 affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-CD89 Antibody; Anti-CTB-61M7.2 Antibody; Anti-FcalphaR Antibody; Anti-FcalphaRI Antibody
Background Information
| Full Name | Fc fragment of IgA receptor |
| Description | FCAR, also called FcαRI or CD89, is a type I transmembrane receptor for Fc region of IgA which is the most abundant immunoglobulin in mucosal areas but is only the second most common antibody isotype in serum. This receptor is present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, especially phagocytes located in mucosal areas. Upon ligand IgA binding, FcαRI associates with the FcR γ signaling molecule bearing the immunoreceptor tyrosine-based activation motif (ITAM) through a unique charge-based mechanism and triggers multiple cell-mediated immune responses. It has been reported that Fc RI is a dual-function receptor that can mediate both inflammatory and anti-inflammatory responses depending on the type of interaction with its ligand. Sustained aggregation of FCAR results in activation of target-cell functions such as antigen presentation and cytokine release. In contrast, Monomeric targeting with serum IgA or with a variety of anti-FcαRI Fab fragments triggers an inhibitory response and additionally induces apoptosis. FcαRI thus play an fundamental role in preventing tumor development and growth, as well as in controlling inflammation. |
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