| Catalog No. | Size | Price (USD) |
| 209175-T08-50 | 50 µL | $147.96 |
| 209175-T08-100 | 100 µL | $251.64 |
| 209175-T08-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-CDC14A Antibody, Rabbit Polyclonal |
| Validated applications | IHC-P (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human CDC14A |
| Immunogen | E. coli-derived Human CDC14A fragment |
| Preparation | Produced in rabbits immunized with E. coli-derived Human CDC14A fragment, and purified by antigen affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | PBS, pH7.0 with 0.03% Proclin300 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-cdc14 Antibody; Anti-Cdc14A1 Antibody; Anti-Cdc14A2 Antibody; Anti-DFNB105 Antibody; Anti-DFNB32 Antibody; Anti-DFNB35 Antibody; Anti-hCDC14 Antibody
Image / Experimental Information
| Image 1 Description | Immunochemical staining of human CDC14A in human testis with rabbit polyclonal antibody at 1:500 dilution, formalin-fixed paraffin embedded sections. |
| Image 1 Alt Text | Human CDC14A Immunohistochemistry(IHC) 30170 |
| Image 1 URL | Source image |
| Image 2 Description | Immunochemical staining of human CDC14A in human testis with rabbit polyclonal antibody at 1:500 dilution, formalin-fixed paraffin embedded sections. |
| Image 2 Alt Text | Human CDC14A Immunohistochemistry(IHC) 30171 |
| Image 2 URL | Source image |
Background Information
| Description | Cdc14 enzymes compose a family of highly conserved phosphatases that are present in a wide range of organisms, including yeast and humans, and that preferentially reverse the phosphorylation of Cyclin-Dependent Kinase (Cdk) substrates. The budding yeast Cdc14 orthologue has essential functions in the control of late mitosis and cytokinesis. In mammals, however, the two Cdc14 homologues, Cdc14A and Cdc14B, do not play a prominent role in controlling late mitotic events, suggesting that some Cdc14 functions are not conserved across species. Cdc14A codes for a conserved proline-directed phosphatase, and mutations in the gene are associated with autosomal-recessive severe to profound deafness, due to defective kinocilia. Human Cdc14A is an evolutionary conserved dual-specificity protein phosphatase that reverses the modifications effected by cyclin-dependent kinases and plays an important role in centrosome duplication and mitotic regulation. |
| Research Areas |
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| References |
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